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Cohort-HMM marker recruitment with per-OG orthology QC for phylogenomic supermatrices
OrthoFinder's all-vs-all DIAMOND step systematically misses single-copy orthogroups (SC OGs) at deep taxonomic divergence: a marker recovered cleanly within a tightly defined cohort is dropped when the same marker is searched against phylum-broad metagenome-assembled genome (MAG) sets, because pairwise sequence similarity falls below DIAMOND's detection threshold even when the underlying ortholog is present. The result is biased dropout - supermatrices that retain genomes near the cohort but...
Toward Culturally Aligned LLMs through Ontology-Guided Multi-Agent Reasoning
arXiv:2601.21700v3 Announce Type: replace Abstract: Large Language Models (LLMs) increasingly support culturally sensitive decision making, yet often exhibit misalignment due to skewed pretraining data and the absence of structured value representations. Existing methods can steer outputs, but often lack demographic grounding and treat values as independent, unstructured signals, reducing consistency and interpretability. We propose OG-MAR, an Ontology-Guided Multi-Agent Reasoning framework.
Structural Connectivity Between the Zinc Linchpin Motif, the cluster, and the active site orchestrates DNA repair in MUTYH
The DNA glycosylase MUTYH protects genomic integrity by excising adenine mispaired with 8-oxoguanine (OG), which initiates base excision repair (BER). The [4Fe-4S] cluster DNA binding domain and Zn linchpin motif of MUTYH are hotspots for inherited cancer associated variants (CAVs) highlighting their critical functions in DNA repair. Here, we present three full-length human MUTYH crystal structures bound to DNA across three catalytic states, representing early and late transition states and...
A limited edition translucent green Xbox Series X and controller are coming this fall
A limited edition translucent green Xbox Series X and controller are coming this fall Xbox’s 25th anniversary collection drops in November. Xbox is releasing a 25th anniversary version of the Series X console and controller in its translucent OG Green. You'll be able to buy the Xbox Series X25 Limited Edition and Xbox Wireless Controller X25 Special Edition together, or separately purchase the controller if you're not looking for a whole new console.
Knicks, Spurs players react as President Trump's Game 3 visit to MSG brings tighter security
Madison Square Garden is not playing around with President Donald Trump's attendance at Game 3.Security has been amped up, and it's rubbing some players the wrong way as the arena braces for its highest-profile guest yet. Even NBA Commissioner Adam Silver has expressed appreciation for Trump's attendance, acknowledging it is a bona fide ratings boost. Players such as Spurs guard De'Aaron Fox and Knicks forward OG Anunoby don't sound nearly as excited.
Microsoft’s Xbox 25th anniversary console comes in translucent green
Microsoft has created a special edition Xbox Series X to celebrate 25 years of the console. The Xbox 25th anniversary console takes design cues from the original Xbox console, with both the console and controller featuring a translucent green design. "For the first time, we're bringing a translucent design to Xbox Series X, drawing inspiration from the original Xbox and OG Green so many players remember," explains Jason Ronald, VP of next generation.
Sources: NBA investigating Brunson-fan incident
The NBA is investigating an interaction between New York Knicks star Jalen Brunson and courtside fans late in the fourth quarter of Game 1 of the NBA Finals, sources confirmed to ESPN. Brunson appeared to be upset with some courtside fans while teammate OG Anunoby was taking a pair of free throws with 29.4 seconds remaining Wednesday in New York's 105-95 victory over the San Antonio Spurs. The Knicks superstar, who made an acrobatic shot on the previous possession to give New York a...
Knicks stay hot, steal Game 1 behind Brunson's 30
SAN ANTONIO -- The New York Knicks' winning streak lives on, and they struck first in the NBA Finals. Jalen Brunson scored 30 points, Karl-Anthony Towns finished with 18 points and 12 rebounds, and the Knicks erased a 14-point second-half deficit to beat the San Antonio Spurs 105-95 in Game 1 of the finals on Wednesday night. OG Anunoby had 17 points for New York, which has won 12 consecutive playoff games, tying the second-longest streak in a single postseason in NBA history.
2026 NBA Finals Game 3: San Antonio Spurs at New York Knicks best bets for the total and two player props
The New York Knicks (2-0) are two wins from their first championship since 1973 as they host the San Antonio Spurs (0-2) for Game 3 of the 2026 NBA Finals Monday. This is a burn-the-boats game for San Antonio since no team has ever come back from a 3-0 deficit to win an NBA playoff series. New York grabbed home-court advantage for the finals by winning the series opener, 105-95.Then, the Spurs gave away Game 2 despite getting a "good whistle" from the refs all night and holding Jalen Brunson...
'A dream matchup': NBA execs, coaches and scouts p...
The 2026 NBA Finals should have something for everyone. The New York Knicks, the standard-bearers of the league's biggest market who hope to snap a 53-year championship drought, enter Wednesday's Game 1 (8:30 p.m. ET, ABC) boasting one of the best playoff stretches in NBA history: 11 straight wins, featuring sweeps of the Philadelphia 76ers and Cleveland Cavaliers.