Polycomb
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Embryos shape their limbs: a key discovery of "genetic brakes"
Canadian scientists have made a significant advance in understanding the mechanisms that enable embryos to properly form their limbs, thanks to new research led by Université de Montréal medical professor Marie Kmita at the Montreal Clinical Research Institute (IRCM). In findings published in the journal PNAS, Kmita and her team highlight the crucial role of certain molecular systems that act as true “genetic brakes,” ensuring that development proceeds correctly. At the very beginning of...
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Correct neural progenitor cell (NPC) fate specification is essential to produce the full complement of neurons and glia needed for proper brain structure and function. Neurodevelopmental disorders, including the autosomal aneuploidy Down syndrome (DS), or Trisomy 21 (T21), are frequently associated with impaired cell fate decisions which ultimately drive differences in overall brain size and cell type composition through unknown mechanisms. To uncover mechanisms driving altered NPC fate in...