Pyramid
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Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer's disease mouse model
Selective neuronal vulnerability is a defining feature of Alzheimer's disease, yet how neurodegeneration unfolds across defined hippocampal CA1 pyramidal neuron populations remains unresolved. Previously, we showed that CA1 pyramidal neurons are organized into molecularly defined laminar cell types that form stable spatial signatures along the longitudinal axis (Pachicano et al., 2025). Here, we investigated how vulnerability manifests across CA1 pyramidal cell types in the 5xFAD mouse model...
Pyramid rings seized in their dozens on way to Appleby Horse Fair
99 pyramid rings seized by police on way to Appleby Horse Fair Cumbria Police issued a warning this morning after officers seized dozens of the rings en route to Appleby Horse Fair, after also seizing BB weaponry and ammunition Police are set to destroy several dozen pyramid rings seized in an early morning bust after citing how similar trinkets were "used to cause significant injury to people". Cumbria Police said this morning that officers had seized 99 rings en route to the Appleby Horse...
Multi-view Pyramid Transformer: Look Coarser to See Broader
arXiv:2512.07806v2 Announce Type: replace Abstract: We propose Multi-view Pyramid Transformer (MVP), a scalable multi-view transformer architecture that directly reconstructs large 3D scenes from tens to hundreds of images in a single forward pass. Drawing on the idea of ``looking broader to see the whole, looking finer to see the details," MVP is built on two core design principles: 1) a local-to-global inter-view hierarchy that gradually broadens the model's perspective from local views to...
Great Pyramid of Giza is remarkably resilient to earthquakes — and it's due to the ancient Egyptians' 'extraordinary' engineering knowledge
The Great Pyramid of Giza in Egypt has stood through several strong earthquakes.
Extending the UXR Point of View Pyramid: A Generative AI-Augmented Methodology for Human-Centred AI Systems
Announce Type: new Abstract: Rising household debt and cost-of-living pressures in the United Kingdom have intensified the role of AI-driven financial technologies in mediating credit assessment, repayment structuring, and debt support services. These systems increasingly shape consequential financial decisions, yet they operate within complex socio-technical environments characterised by regulatory constraint, algorithmic opacity, and heightened vulnerability risk. User Experience Research...
What can a neuron compute
Cortical pyramidal neurons possess elaborate dendritic trees with diverse nonlinear membrane conductances and thousands of plastic synapses, suggesting substantial computational capabilities at the single-cell level. Yet, what can a neuron compute remains an open question, largely due to the lack of a systematic framework to quantify its computational capabilities. We introduce TwinProp, a digital-twin-based backpropagation algorithm that enables gradient-based optimization of synaptic...
WSL2 side Durham warn they will ‘cease operations’ without cash injection in 21 days
‘Do not have sufficient funds to operate in 26-27 season’Talks with potential investors ‘have fallen away’Durham, the Women’s Super League 2 side, have issued an urgent plea for funding and warned that they will have to “cease operations” if they cannot find fresh investment within the next 21 days. The independently run club, who are not affiliated to a professional men’s side, have been competing in the second tier of the English women’s football pyramid for 12 years, but say their owners...
‘Like a Klingon prison’: inside Barack Obama’s audacious, near-windowless, $850m presidential library
Towering over a low-income area of Chicago, and wrapped in a speech that’s hard to decipher, this controversial monolith feels like a menacing sci-fi HQ. Is it a monument – or a mausoleum?The Egyptians had their pyramids. The Anglo-Saxons had their barrows.
PRISM: Progressive Reasoning through Iterative Slot Memory for Vision
Announce Type: new Abstract: Modern vision models process images in a single feed-forward pass, which limits their ability to recover missing evidence or refine uncertain representations under incomplete observations. Inspired by the iterative nature of human perception, we introduce PRISM (Progressive Reasoning through Iterative Slot Memory), a pyramid vision architecture that reasons over images through iterative refinement. At a high level, PRISM groups visual features into object-centric...
WSL2 side Durham warn they will ‘cease operations’ without cash injection in 21 days
‘Do not have sufficient funds to operate in 26-27 season’Talks with potential investors ‘have fallen away’Durham, the Women’s Super League 2 side, have issued an urgent plea for funding and warned that they will have to “cease operations” if they cannot find fresh investment within the next 21 days. The independently run club, who are not affiliated to a professional men’s side, have been competing in the second tier of the English women’s football pyramid for 12 years, but say their owners...