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Related Articles from SNS
Predictable Compression Failures: Order Sensitivity and Information Budgeting for Evidence-Grounded Binary Adjudication
arXiv:2509.11208v3 Announce Type: replace-cross Abstract: Transformers used for evidence-grounded binary adjudication (e.g., support/refute, yes/no, or verifier-backed pass/fail decisions) can be sensitive to the order in which exchangeable evidence is presented, producing dispersion across permutations and unreliable attempted answers under a verifier-relative Bernoulli predicate. We treat evidence order as a nuisance variable and formalize an expectation-realization gap: next-token...
Inbreeding depression by polygenic load following a severe population bottleneck
It is poorly understood how populations survive extreme bottlenecks despite severe inbreeding. We investigate the genomic architecture of inbreeding in the once critically endangered Seychelles warbler (Acrocephalus sechellensis) using 37 years of individual-based monitoring and 1.8 million SNPs. Linkage disequilibrium patterns reveal a historical effective population size of ~270 that plummeted to ~13 coinciding with human colonisation events of the Seychelles archipelago.
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).