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Sound Event Detection with Boundary-Aware Optimization and Inference
arXiv:2601.04178v2 Announce Type: replace-cross Abstract: Temporal detection problems appear in many fields including time-series estimation, activity recognition and sound event detection (SED). In this work, we propose a new approach to temporal event modeling by explicitly modeling event onsets and offsets, and by introducing boundary-aware optimization and inference strategies that substantially enhance temporal event detection. The presented methodology incorporates new temporal...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Sussex widow sues artisan cheesemaker for £200k after husband dies from infected Valentine’s gift
Sussex widow sues artisan cheesemaker for £200k after husband dies from infected Valentine’s gift Painter Roger Parkes died just days after consuming the cheese - Bookmark A West Sussex artist's widow is suing for over £200,000 after her husband died from a listeria infection, contracted from an artisan cheese she bought him as a Valentine's gift. Painter Roger Parkes became seriously ill and died in February 2023, days after consuming a 'Baronet' Reblochon cheese from a 'Valentine box'...
Pulsar wind nebula inside supernova remnant explored with Chandra
May 30, 2026 report Pulsar wind nebula inside supernova remnant explored with Chandra Tomasz Nowakowski Author Gaby Clark Scientific Editor Robert Egan Associate Editor Astronomers from the George Washington University (GWU) in Washington, DC, and elsewhere have employed NASA's Chandra X-ray spacecraft to observe a pulsar wind nebula inside a supernova remnant known as CTA 1. Results of the observational campaign, presented in a research paper published May 20 on the arXiv preprint server,...
Ask HN: What are tools you have made for yourself since the advent of AI?
I've made a number of ceramic molds for slumping fused glass into bowls. As well as wooden templates for ceramic mugs. I've devised a few carrying tools to move glass frit paintings from my studio down to my barn where the kilns sit without spilling the glass.
Distant blazar OP 313 emits very high-energy gamma rays above 100 GeV
June 3, 2026 report Distant blazar OP 313 emits very high-energy gamma rays above 100 GeV Tomasz Nowakowski Author Stephanie Baum Scientific Editor Robert Egan Associate Editor An international team of astronomers have employed one of the Large-Sized Telescopes (LSTs) at the Cherenkov Telescope Array Observatory (CTAO) to observe a distant blazar known as OP 313. Results of the observational campaign, published May 26 on the arXiv preprint server, shed more light on the behavior and nature...
Self-hosted dev sandboxes with preview URLs (Docker, Go, no K8s)
The open-source engine for AI app-builder products. Give every user an isolated cloud dev environment, a built-in coding agent, and a live preview URL — self-hosted, on one machine, in one command. Think of the apps where you type "build me a todo app" and seconds later a working website appears at its own link — like Lovable, Bolt, v0, or Replit. sandboxed is the open-source backend that makes that possible, running on your own server.
macOS Container Machines
Container machine provides a highly integrated Linux environment that works seamlessly on your Mac. Container machines are fast, lightweight and persistent. They are based on standard OCI images that can be built and shared.
TV doctor's urgent warfarin, tetracyclines, ciprofloxacin and statins alert over supplements
TV doctor's urgent warfarin, tetracyclines, ciprofloxacin and statins alert over supplements Dr Amir Khan who has appeared on ITV's This Morning said people need to check with their doctor if they’re on certain medications A TV doctor has issued an urgent alert for anyone taking warfarin, tetracyclines, ciprofloxacin and some statins - because some supplements will interfere with how they work. Speaking today on Instagram Dr Amir Khan, who has appeared on This Morning and Lorraine explained...
Conviction of Aussie band's 'sixth member' reveals Byron Bay's dark side
Women reveal Byron Bay's predatory 2000s culture of rape, humiliation and shame Mon 1 Jun 2026 at 6:01am The girl in the photo is smiling for the camera, her hair in a side ponytail, a trucker cap on her head. In another snap, she looks into the distance, standing in front of a stretch of palm trees with fronds glossy and green from the damp air of Byron Bay.