SEM
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Related Articles from SNS
$\mathrm{ECI}_{\mathrm{sem}}$: Semantic Residual Effective Contrastive Information for Evaluating Hard Negatives
arXiv:2603.20990v3 Announce Type: replace Abstract: Hard-negative source selection for dense retrieval is usually decided only after fine-tuning and downstream evaluation. We propose $\mathrm{ECI}_{\mathrm{sem}}$, a semantic residual variant of Effective Contrastive Information (ECI) that ranks candidate negative sources using frozen target-encoder embeddings. $\mathrm{ECI}_{\mathrm{sem}}$ is training-free, not label-free: each scored example requires a query, a labeled positive, and an...
Ultra-Fast Implementation of Multivariate GWAS in Genomic SEM Using Flexible Analytic Estimation
Many medical, physiological, and psychiatric traits and disorders are highly polygenic and exhibit complex patterns of genetic sharing and differentiation. In 2018, we introduced Genomic Structural Equation Modelling (Genomic SEM) as a formal framework and free, open source, R-based software for modelling the multivariate genetic architecture of both continuous and binary Genome-Wide Association Study (GWAS) phenotypes, interrogating their joint and distinct functional genomic pathways, and...
Sem: New primitive for code understanding – not LSPs, but entities on top of Git
Semantic understanding on top of Git. Diff, blame, impact, log. Functions, not lines.
Sem-NaVAE: Semantically-Guided Outdoor Mapless Navigation via Generative Trajectory Priors
Announce Type: replace Abstract: This work presents a mapless navigation approach for outdoor applications. It combines the exploratory capacity of conditional variational autoencoders (CVAEs) to generate trajectories and the semantic segmentation capabilities of a lightweight visual language model (VLM) to select the trajectory to execute. Open-vocabulary segmentation is used to score and select the generated trajectories based on natural language, and a state-of-the-art local planner...
California high school graduation shooting kills teen, injures child and two others
An 18-year-old student was killed and three other people, including an 11-year-old child, were wounded in a shooting Wednesday evening during a high school graduation event in Northern California, police said. The shooting occurred during a Sem Yeto High School graduation ceremony held at Fairfield High School, according to authorities. Fairfield Police Officer Michelle Belyea said three victims who suffered gunshot wounds were ages 11, 20 and 25.
iSBEM: An Open-Source Workflow for Automated ROI Targeting in Volume Electron Microscopy
Serial Block Face - Scanning Electron Microscopy (SBF-SEM) is a volume EM method suited to investigate the 3D architecture of tissues and even entire organisms at high resolution. However, imaging large volumes in their entirety is time-consuming and not always necessary. Many research projects have a focused interest in well-defined sub-regions of the samples.
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Design and electron optics performance of a MEMS electrostatic electron monochromator
arXiv:2606.09423v1 Announce Type: new Abstract: Monochromators are routinely used in Transmission Electron Microscopy and Electron Energy Loss Spectroscopy, to improve both spatial and energy resolution. State-of-the-art monochromators, however, are complex instruments that typically require additional electron optical correctors, limiting their implementation to the high-end, most expensive microscopes. Miniaturized monochromation relying on purely electrostatic fringe fields has recently...
Evaluating and Learning Robust Bandit Policies Under Uncertain Causal Mechanisms
Announce Type: replace Abstract: Causal graphical models can encode large amounts structural knowledge, both from the background knowledge of domain experts and the structural knowledge discovered from randomized experiments or observational data. However, though we may know the general structure of causal relationships, we often do not know the exact causal mechanisms. In this work, we propose a causal multi-armed bandit evaluation and learning algorithm that can reason effectively despite...