Spearman
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ArrowFlow: Hierarchical Machine Learning in the Space of Permutations
Announce Type: replace Abstract: We introduce ArrowFlow, a machine learning architecture that operates entirely in the space of permutations. Its computational units are ranking filters, learned orderings that compare inputs via Spearman's footrule distance and update through permutation-matrix accumulation, a non-gradient rule rooted in displacement evidence. Layers compose hierarchically: each layer's output ranking becomes the next layer's input, enabling deep ordinal representation...
MIRAI: Prediction and Generation of High-Impact Academic Research
arXiv:2606.05443v1 Announce Type: new Abstract: The rapid pace of scientific publishing has made the identification and synthesis of high-impact work an increasingly urgent challenge. We introduce MIRAI (Multi-year Inference of Research trends and Academic Impact), a deep learning framework that predicts paper impact using only it's title, abstract, and publication date. We train MIRAI on the arXiv academic graph to predict 5-year PageRank and citation counts, achieving Spearman's $\rho$ of...
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
EndoTwin-W: glycodelin-A and CA-125 as non-invasive biomarkers of endometrial receptivity derived from a multiscale computational digital twin
Endometrial receptivity assessment currently requires invasive tissue biopsy, yet recent randomized trials have questioned the clinical utility of biopsy-based approaches. Here we present EndoTwin-W, a four-layer mechanistic computational model that simulates human endometrial remodeling from hormone inputs through receptor binding, pathway scoring, and continuous-time Markov chain cell-state transitions across 17 cell states. Transition rates were optimized against scRNA-seq and microarray...
Genomic-Adjusted Radiation Dose from Bulk RNA Sequencing for Personalized Radiotherapy
Radiotherapy is delivered to more than half of all patients with cancer yet is prescribed using uniform physical doses despite well-established interpatient variability in biological response. The genomic-adjusted radiation dose (GARD), derived from the radiosensitivity index (RSI), integrates tumor transcriptomics with radiation dose to estimate patient-specific treatment effect, and has been clinically validated as a predictor of radiotherapy benefit across diverse disease sites, including...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
A Lightweight Ensemble-Based Face Image Quality Assessment Method with Correlation-Aware Loss
arXiv:2509.10114v2 Announce Type: replace Abstract: Face image quality assessment (FIQA) plays a critical role in face recognition and verification systems, especially in uncontrolled, real-world environments. Although several methods have been proposed, general-purpose no-reference image quality assessment techniques often fail to capture face-specific degradations. Meanwhile, state-of-the-art FIQA models tend to be computationally intensive, limiting their practical applicability.
FASE: Fast Adaptive Semantic Entropy for Code Quality
arXiv:2606.09800v1 Announce Type: new Abstract: Multi-agent code generation offers a promising paradigm for autonomous software development by simulating the human software engineering lifecycle. However, system reliability remains hindered by LLM hallucinations and error propagation across interacting agents. While semantic entropy provides a principled way to quantify uncertainty without ground-truth answers, current methods often rely on costly LLM-driven equivalence checks.
Precision Is Not Faithfulness: Coverage-Aware Evaluation of Grounded Generation with a Complete Oracle
Announce Type: new Abstract: Reference-free faithfulness metrics verify each atomic claim a model makes against ground truth, and are increasingly used to evaluate grounded generation. We show they share a blind spot: they measure only precision -- are the stated claims supported? -- and therefore reward abstention, since a model can score near-perfect faithfulness by saying almost nothing.
Efficient Benchmarking Is Just Feature Selection and Multiple Regression
Announce Type: replace-cross Abstract: Efficient benchmarking techniques aim to lower the computational cost of evaluating LLMs by predicting full benchmark scores using only a subset of a benchmark's questions. By reframing this problem as an instance of multiple regression with feature selection, we find that existing efficient benchmarking methods can be greatly improved by simply using kernel ridge regression at the prediction stage. Additionally, using an information-theoretic...