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Multiscale Dynamics of Heatwave Persistence and Intensity Under Climate Change

Announce Type: new Abstract: Climate change is expected to increase heatwave risk, but exceedance frequency alone cannot explain why some regions show stronger amplification in event persistence. This study develops an integrated event-dynamical workflow to diagnose changes in warm-season heatwaves and link them to coherent, multiscale structures of temperature variability. Heatwaves are identified over southern Canada using a fixed historical 90th percentile threshold (2001-2010 reference,...

arXiv Physics 8d ago

Whole-genome duplication shaped cell-type evolution in the vertebrate brain

Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...

Nature 20h ago

A prognostic human brain network for diffuse midline glioma

Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.

Nature 20h ago