Survival Topologies
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A Pan-Cancer Multi-Omic SuperLearner for Regulated Cell Death Survival Topologies
Introduction: Regulated cell death (RCD) pathways profoundly influence tumor progression and immune modulation. In prior work, we constructed a comprehensive database mapping 25 forms of RCD across seven multi-omic layers encompassing 33 tumor types (CancerRCDShiny). Despite their robust ability to identify risk populations, translating these prognostic signatures into personalized clinical workflows requires a shift from generalized cohort stratification to individualized risk mapping.
Graph Mamba Survival Analysis Based on Topology-Aware ordering
arXiv:2606.02602v1 Announce Type: new Abstract: In computational pathology, Whole Slide Images (WSIs) survival analysis is crucial for patient prognosis assessment, but it faces multiple technical challenges. Although the Transformer captures long-range dependencies through its self-attention mechanism, its $O(N^2)$ time complexity causes a severe computational bottleneck in large-scale WSIs graph structures. The Mamba model breaks through the Transformer's computational bottleneck with...
Rashomon Memory: Towards Argumentation-Driven Retrieval for Multi-Perspective Agent Memory
Announce Type: replace Abstract: AI agents operating over extended time horizons accumulate experiences that serve multiple concurrent goals, and must often maintain conflicting interpretations of the same events. A concession during a client negotiation encodes as a ``trust-building investment'' for one strategic goal and a ``contractual liability'' for another. Current memory architectures assume a single correct encoding, or at best support multiple views over unified storage.
Microsoft launches its own AI models to take on OpenAI and Anthropic
Seven in-house models unveiled at Build 2026 signal Microsoft's push to cut costs and compete directly on the AI frontier as its biggest investees plan to launch record-breaking IPOs. Microsoft has unveiled a family of seven in-house AI models at its annual Build developer conference in San Francisco, in the clearest sign yet that the tech giant is moving to reduce its dependence on the AI companies it has poured billions into. Mustafa Suleyman, Microsoft AI chief executive, said that after...
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.