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TB vaccine from the 1920s shows promise in diabetes trial
Nature, Published online: 09 June 2026; doi:10.1038/d41586-026-01825-wThe shot reduced insulin use for people with type 1 diabetes and another autoimmune condition.
Calorie Restriction-Induced Daily Hibernation in Mice Drives Cyclic DNA Damage and Repair
Hibernation consists of bouts of torpor, characterized by profound decreases in metabolism and body temperature (Tb), alternated with periods of euthermia called interbout arousals, during which normal metabolism and Tb resume. Seasonal hibernators accumulate DNA strand breaks during torpor, which are repaired during arousal. Here, we assess dynamics of DNA damage and repair during serial daily torpor in mice induced by 30% calorie restriction (CR) and investigate the effects of metabolic...
Clustering Guided Domain-Specific Pretrained Foundation Model Very High-Resolution Arctic Remote Sensing
new Abstract: This study introduces a novel Arctic-focused remote sensing foundation model (RSFM) by combining diversity-aware regional-scale image curation with masked autoencoder (MAE) self-supervised pretraining of a Vision Transformer (ViT) encoder for very-high-spatial-resolution (VHSR) satellite image analysis. Spectral and acquisition-metadata descriptors were used in a scalable affinity-propagation clustering workflow to select approximately 3 million chips from 267 TB of Vantor VHSR...
Can China fill funding and leadership gaps after America quit the WHO?
Can China fill funding and leadership gaps after America quit the WHO? Beijing is now the global health body’s biggest assessed contributor, but its voluntary donations remained low in 2025 “I’m here to lobby for support,” said Jenny Stephens, Vanuatu’s director of public health. “We are experiencing the global funding cuts – it’s affecting our programmes like malaria, TB and HIV.
Researchers discover how to turn one germ's drug resistance into an Achilles' heel
Researchers discover how to turn one germ's drug resistance into an Achilles' heel Lisa Lock Scientific Editor Andrew Zinin Lead Editor Decades of reliance on the antibiotic rifampicin have fueled the rise of drug-resistant Mycobacterium tuberculosis (Mtb). But as the bacterium mutates to protect itself from the drug, it also creates new weak points that other therapies could exploit. Now, a new study published in Nature Microbiology shows that the most common rifampicin-resistance mutation...
Fantasy Baseball Forecaster for Week 10: June 1-7
Week 10 marks the turn of the calendar to June. The first week of the month brings a relatively quiet 93-game week, beginning with nine evening affairs on Monday. Tuesday features 15 games under the lights, with the first matinee set for Wednesday.
Preventing the Breakdown of Tight-Binding Waveguide Optics by L\"owdin Orthogonalization
arXiv:2605.31074v1 Announce Type: new Abstract: Many advancements in optics have relied on the tight-binding approximation, which simplifies the description and prediction of complex system behaviors. This approximation describes the dynamics of the total light field by examining the coupling between the guided modes of individual single-mode substructures -- also known as coupled mode theory. However, the underlying assumption, that the guided modes of individual waveguides form an...
Castor: CERN Advanced STORage Manager
The CERN Advanced STORage manager (CASTOR) is a hierarchical storage (i.e. has disk and tape) management system which was developed at CERN for archiving physics data (with very large data volumes, see the plot on the right). Files can be stored, listed, retrieved and remotely accessed using CASTOR command-line tools or user applications that were developed using the CASTOR API. CASTOR provides a set of access protocols such as XROOT (the main and recommended protocol) and GridFTP.
Replicate-anchored calibration of within-host single nucleotide variant detection in Mycobacterium tuberculosis whole genome sequencing
Intra-host genetic heterogeneity in Mycobacterium tuberculosis is biologically and clinically informative, but its detection from short read whole genome sequencing depends on thresholds over read depth (DP), alternate allele support (AD), and minor allele frequency (MAF) that are rarely empirically anchored. We developed a biological replicate-anchored, lexicographic calibration framework for per-specimen intra-host single nucleotide variant (iSNV) detection. Within-patient replicate sputum...
Silurus/ooxml: Pixel-faithful Office documents, rendered in the browser
This entire codebase — Rust parsers, TypeScript renderers, tests, and tooling — was implemented by Claude (Anthropic's AI assistant) through iterative prompting. No human-written application code exists in this repository. A browser-based viewer for Office Open XML documents that renders to an HTML Canvas element.