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One vehicle, two fuels: India bets big on flex-fuel revolution - what is it?
India’s push for flex-fuel vehicles can help meet twin national goals of cutting crude oil imports and reducing carbon emissions, but will require a full supporting ecosystem from fuel availability to wider model launches, Maruti Suzuki India MD and CEO Hisashi Takeuchi said on Thursday. Speaking at the launch of the company’s first flex-fuel car, Wagon R, Takeuchi said the technology offers benefits that extend beyond the automobile sector, supporting farmers, ethanol producers and the...
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Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).