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Related Articles from SNS
A Novel Global Context-aware Deep Neural Network for Enhanced Brain Tumor Segmentation using Magnetic Resonance Images
arXiv:2605.30510v1 Announce Type: new Abstract: Brain cancer's severity necessitates precise brain tumor segmentation, which is crucial for effective brain tumor diagnosis. Manual identification, burdened by high costs, labor, and error risks, highlights the need for automated methods. In this study, we introduce the Global Context-aware Squeeze and Excite Residual UNet (GCSER-UNet), which facilitates a fusion of spatial and channel-wise attention and thus enhances the model's capacity to...
Single-Cell Multi-Omics Dissection of Malignant Evolutionary Mechanisms and Construction of a Prognostic Model for Clear Cell Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC) exhibits pronounced heterogeneity across WHO histological grades, yet systematic single-cell multi-omics studies characterizing these transitions remain limited. We integrated scRNA-seq and scATAC-seq data across ccRCC WHO grades to establish a multi-omics framework encompassing tumor cells and immune populations. Using pseudotime trajectory analysis and machine learning ensembles, we developed a prognostic signature (CBG) from core nodes of...
Quantifying thermal-signature equivalence in infrared breast thermography using a modified Pennes bioheat model
arXiv:2605.05713v2 Announce Type: replace Abstract: Infrared breast thermography provides a noninvasive measurement of skin-surface temperature, but the relation between surface thermal patterns and intratumoral physiology is limited by heat diffusion and thermal screening. Here we study a steady-state modified Pennes bioheat model in a two-dimensional multilayer breast-tissue cross-section containing a finite-sized tumor with spatially heterogeneous perfusion. We compare four idealized...
Convergent Evolution in Tumor Genomes Targets Functional Domains
Tumor evolution is shaped by selective pressures that repeatedly favor similar functional outcomes across genetically distinct cancers. While convergent evolution in cancer has been studied at the gene level, this work investigates selection on smaller functional units, namely protein domains. Using >9,500 primary tumor exomes from The Cancer Genome Atlas, we quantified selection strengths acting on missense and truncating mutations aggregated by protein domain.
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Cancer’s favorite escape trick may actually make it easier to kill
Cancer’s favorite escape trick may actually make it easier to kill - Date: - June 4, 2026 - Source: - Baylor College of Medicine - Summary: - Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a key immune-recognition molecule called MHC I—a common trick used to hide from “killer” T cells—they can actually become more vulnerable to attack by a...
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Hair-size microrobots combine three cancer-fighting functions in preclinical animal tests
Hair-size microrobots combine three cancer-fighting functions in preclinical animal tests Gaby Clark Scientific Editor Andrew Zinin Lead Editor Imagine a future where cancer treatment affects only the tumor, where eye injections are no longer required and brain surgeries don't result in large incisions or long recovery times. That's the future researchers at Michigan State University are working toward. Their goal is to make medical care easier on patients by using tiny biodegradable tools...
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features
Cancer arises from extensive genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To systematically chart cancer-intrinsic regulatory programs, we constructed a pan-cancer single-cell transcriptomic and epigenomic atlas encompassing 60 human cell lines representing 16 tissue origins and 20 cancer types, comprising 240,957 single-nucleus RNA-seq and 223,347 single-nucleus ATAC-seq profiles. Integrative analyses revealed extensive...