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Zebrafish microbiome model enhanced by simple trick
Zebrafish microbiome model enhanced by simple trick Lisa Lock Scientific Editor Andrew Zinin Lead Editor A new advance in animal husbandry involving a popular aquarium fish should speed the pace of discovery in laboratory studies of host-microbe interactions, researchers report. The new findings by researchers from the University of Illinois Urbana-Champaign are detailed in the journal mSystems. Zebrafish are desirable study animals because one pair can produce hundreds of offspring in a day...
DanioDecima: A DNA sequence-to-function model of zebrafish embryogenesis
Deep learning DNA sequence-to-function models offer the promise of gaining mechanistic insights into genome regulation, however their performance is often limited by data scarcity in the species of interest. We present DanioDecima, a zebrafish-specific model leveraging transfer learning from human and mouse-trained models to predict tissue- and cell-type-specific gene expression during zebrafish embryogenesis. Initializing DanioDecima with pretrained human and mouse Borzoi and Decima weights...
Validation of optogenetic approach to investigate fatigable weakness using a zebrafish model of congenital myasthenic syndrome
Congenital myasthenic syndromes (CMS) are rare inherited diseases of the neuromuscular junction (NMJ). There are 40 identified CMS genes, but many patients go without genetic diagnosis, which suggests new genes have yet to be discovered and characterised. Here, we describe an optogenetic approach to study fatigable muscle weakness and NMJ function in larval zebrafish to facilitate screening approaches for uncovering novel CMS genes.
Rab8a-positive vesicles transport Wnt8a along cytonemes in zebrafish embryogenesis.
Wnt signalling is a conserved pathway that orchestrates key developmental processes by regulating cell fate, proliferation, and tissue organisation. While the production and secretion of Wnt ligands are well characterised, less is known about how lipid-modified Wnts are delivered for long-range communication. Recently, cytonemes - actin-based signalling filopodia - have been identified as transporters of Wnts over distances to target specific cells in embryogenesis.
Your brain starts making social decisions before you do
Your brain starts making social decisions before you do - Date: - June 2, 2026 - Source: - The Hebrew University of Jerusalem - Summary: - Researchers found that social behavior begins in the brain before it becomes visible as movement. In zebrafish, a coordinated pattern of activity spread across the brain several seconds before the animals approached another fish. A higher brain region called the pallium played a key role, and fish with stronger neural signals were generally more social.
Fish Sleep a Lot Like Us. (They Even Nap.)
By tracking eye movements in zebrafish, researchers identified four different types of sleep, analogous to the complex sleep patterns of humans and other animals.
Daily briefing: Gene-activity ‘clock’ predicts biological ageing
Nature, Published online: 28 May 2026; doi:10.1038/d41586-026-01734-yThe new tool can predict ageing in rodents and monkeys — and time to death in people. Plus, zebrafish sleep in stages, similarly to humans, and the race to intercept lung cancer before it starts.
Natural sunscreen found in fish eggs can be made by E. coli factories
Genetically altered bacteria can synthesise gadusol, a naturally occurring compound found in zebrafish eggs that could be developed as an alternative to existing sunscreen products that can harm marine life
A thalamus–brainstem attractor network drives history-biased decisions
Abstract Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial dependence1,2,3. Large-scale recordings during behaviour have identified that serial dependence is a common motif for decision-making, with neural representations of past experiences found throughout the brain4,5,6,7,8,9,10,11. However, it remains unclear whether this bias arises from dedicated neural circuits with history-specific...
Biohybrid microrobots repair spinal cord by combining stem cells with magnetoelectric nanoparticles
Biohybrid microrobots repair spinal cord by combining stem cells with magnetoelectric nanoparticles Sadie Harley Scientific Editor Robert Egan Associate Editor Spinal cord injuries can have devastating consequences for those affected. Nerve cells in the spinal cord rarely regenerate naturally, while scarring often prevents the regrowth of nerve fibers. Modern therapies attempt to influence implanted stem cells using electrical stimulation to promote the growth of new nerve cells.