anti-MDA5
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Related Articles from SNS
Anti-Melanoma Differentiation-Associated protein 5 Auto-Antibodies Promote a Profibrotic Phenotype in a Human Lung Fibroblast Cell Line
Anti-melanoma differentiation-associated protein 5 (anti-MDA5) autoantibodies identify a distinct dermatomyositis subset frequently associated with rapidly progressive interstitial lung disease (RP-ILD). While these antibodies are established disease markers, their direct contribution to pulmonary fibrosis is poorly defined. This study investigated the pathogenic effects of patient-derived polyclonal anti-MDA5 antibodies on IMR-90 human lung fibroblasts.