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CURE-like, not cure-all: Varying broad relevance in experimentation labs produces similar student outcomes
Announce Type: new Abstract: Physics labs that engage students in practices authentic to experimental physics (experimentation-based labs) are being implemented to modernize the undergraduate physics curriculum and broaden participation in physics. Accordingly, prior research has positioned Course-Based Undergraduate Research Experiences (CUREs) as a means to extend the benefits of authentic undergraduate research experiences to more students. However, CUREs are resource-intensive and...
Species- and Topic-aware Representation Learning for Antimicrobial Peptide Discovery
Antimicrobial resistance poses a major global health challenge, necessitating efficient strategies to discover potent antimicrobial peptides (AMPs). While recent generative models can produce many candidate sequences, experimentally validating all generated peptides in wet labs is impractical due to the high costs and time involved in such measurements. As a result, there is a strong demand for accurate predictions of peptide efficacy, typically measured as the minimum inhibitory...
From hybrids to 'virgin birth,' stick insects reveal stepwise loss of sex
From hybrids to 'virgin birth,' stick insects reveal stepwise loss of sex Lisa Lock Scientific Editor Robert Egan Associate Editor The evolution of sex remains one of biology's greatest puzzles. While sexual reproduction dominates across the animal kingdom, scientists still debate why it persists despite its high costs. Even more mysterious is the loss of sex in favor of asexual reproduction whereby females give birth to copies of themselves without any contribution from males.
Why can't we figure out how strong gravity is?
Why can't we figure out how strong gravity is? Despite dozens of experiments over the years, scientists still don't have a precise measurement for gravity's strength. Of the four fundamental forces of nature, gravity is the one we experience most directly — it's what keeps our feet on the ground and the sun in the sky.
Superintelligence: The Idea That Eats Smart People (2016)
This is the text version of a talk I gave on October 29, 2016, at Web Camp Zagreb [video] (45 mins) SuperintelligenceThe Idea That Eats Smart People | | | In 1945, as American physicists were preparing to test the atomic bomb, it occurred to someone to ask if such a test could set the atmosphere on fire. This was a legitimate concern.
A Drug-Target Specificity Foundation Model for Off-target Prediction, Repurposing, and Generative Design
Molecular recognition - which small molecule binds which protein, and with what selectivity - governs the efficacy, safety, and discovery of every therapeutic, yet binding specificity is still determined by experimental screening or by computational methods that first predict three-dimensional structure. Transformer softmax attention is mathematically isomorphic to the Boltzmann distribution governing molecular binding at thermal equilibrium, an identity that prescribes a single...
Size, Shape, and Material matter: All-optical Mie void sensor for complex nanoplastic mixtures
Announce Type: new Abstract: The fragmentation of plastic debris and the direct release of nanoplastics have emerged as a pressing ecological concern. Once dispersed, these enduring particles infiltrate food webs, accumulate within organisms, and bind toxic co-contaminants, posing long-term risks to ecosystems and human health. Despite growing awareness, the detection and characterization of nanoplastics remain highly challenging due to their minute size.
Googly-eyed robot gives dementia-stricken husband his freedom back - and his exhausted wife a much-needed break
Googly-eyed robot gives dementia-stricken husband his freedom back - and his exhausted wife a much-needed break The decades-long quest to build home robots that are both helpful and lifelike — spurred on by fictional machines like The Jetsons’ humanoid maid Rosie —- is still mostly a pipe dream, but some developers are getting closer - Bookmark Robbie, a caregiver robot, now rolls into their living room several times a day, offering crucial support to Brenda and Brian Marquis, who faced...
AI Is Slowing Down
If you liked this piece, you should subscribe to my premium newsletter. It’s $70 a year, or $7 a month, and in return you get a weekly newsletter that’s usually anywhere from 5,000 to 18,000 words, including vast, detailed analyses of NVIDIA, Anthropic and OpenAI’s finances, and the AI bubble writ large (updated to version 3.0 last week). My Hater's Guides To the SaaSpocalypse, Private Credit and Private Equity are essential to understanding our current financial system, and my guide to how...
Developmental genetic response of the zooplanktonic tunicate Oikopleura dioica to marine noise pollution.
Background: Anthropogenic noise is an emerging threat to marine ecosystems, yet its effects on marine invertebrates, particularly zooplanktonic species, remain poorly understood. Despite increasing evidence of behavioral and physiological impacts in invertebrates, the effects of noise on embryonic development and the molecular mechanisms underlying acoustic responses remain largely unexplored. Here, to address this gap, we investigated the impact of high-intensity underwater noise exposure...