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President Donald Trump was loudly booed at Madison Square Garden in New York City on Monday night before the start of game three of the NBA Finals between the home team Knicks and the San Antonio Spurs. The boos were thunderous in the Garden when Trump was shown on the Jumbotron with Knicks owner James Dolan in a suite well above the court during the playing of the National Anthem. The boos turned to cheers when the Jumbotron's focus turned to Knicks star Jalen Brunson shown standing on the...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
A prognostic human brain network for diffuse midline glioma
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How to Save the Supreme Court From Itself
Subscribe here: Apple Podcasts | Spotify | YouTubeIn this episode of The David Frum Show, The Atlantic’s David Frum opens with his thoughts on growing extremism in the Democratic Party. Frum compares this to the paranoia and conspiratorial thinking that cost the Republican Party dearly in the 2010s and cautions the Democrats against making the same mistakes. Then David is joined by Kate Shaw, a co-host of the podcast Strict Scrutiny and a professor of law at University of Pennsylvania Carey...
Transcriptomic profiling of the human habenula reveals a shared molecular architecture across mood disorders
The habenula is a critical regulator of monoaminergic and reward circuitry and is increasingly implicated in the neurobiology of mood disorders. Preclinical studies demonstrate that habenula hyperactivity drives depressive-like behaviours and can be reversed by interventions such as ketamine and deep brain stimulation. However, the molecular architecture of the human habenula remains largely unexplored.
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The Left Needs to Rediscover Its Patriotism
One the eve of the 250th anniversary of the nation’s independence, more Americans on the right than on the left say they feel patriotic. Recent polls show that a majority of Democrats are “proud” of the country only when a president of their party is in the White House. And many progressive activists and historians see the founding of the nation as a tragedy for Native Americans and enslaved people instead of the glorious fight for liberty that conservatives insist it was.