the International Brain Laboratory
No mentions found
This entity hasn't been tracked yet, or Iris is still building its knowledge base.
Related Articles from SNS
Bracket Coding: The Optimal Balance Between Temporal Integration and Segregation in Early Visual Processing
Despite over a century of research into the neural code, the fundamental principles by which the brain encodes sensory information remain debated. In this study we provide converging evidence for the presence of a dynamic, fast-switching integration of rate and temporal coding in the thalamus, primary visual cortex, and higher-order visual cortical areas of mice viewing an array of visual stimuli. This scheme is primarily characterized by the presence of distinct, temporally coordinated...
Computational Design of Two New 5-HT1B Serotonin Receptor Agonists Derived from Naratriptan
Migraine headaches affect over one billion people internationally and can be defined as episodes of acute severe pain wrapping around the head and are normally accompanied by nausea, blurry vision, and sensitivity to light and sound. While triggers that cause migraines may vary among patients, evidence shows they are involved with the trigeminovascular system (a network of blood vessels in the brain in conjunction with the trigeminal nerve). Activation of the trigeminal neurons triggers the...
The Frame Problem
The Frame Problem To most AI researchers, the frame problem is the challenge of representing the effects of action in logic without having to represent explicitly a large number of intuitively obvious non-effects. But to many philosophers, the AI researchers' frame problem is suggestive of wider epistemological issues. Is it possible, in principle, to limit the scope of the reasoning required to derive the consequences of an action?
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
When drug discovery fails: scientists share their frustrations with the process
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).
Efficient and accurate neural-field reconstruction using resistive memory
Abstract Applications such as medical imaging, augmented and virtual reality, and embodied artificial intelligence (AI) depend on the ability to reconstruct complex signals from sparse observations. These applications are characterized by incomplete measurements and limited computational resources. Traditional approaches to digital hardware face the following challenges: explicit signal representations require heavy sampling and storage, data movement across the von Neumann bottleneck...
A thalamus–brainstem attractor network drives history-biased decisions
Abstract Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial dependence1,2,3. Large-scale recordings during behaviour have identified that serial dependence is a common motif for decision-making, with neural representations of past experiences found throughout the brain4,5,6,7,8,9,10,11. However, it remains unclear whether this bias arises from dedicated neural circuits with history-specific...
Ahoy, DECmate II the little PDP-8 that could
Now, that's a lot of word processing. But under the hood it's still at least PDP-8 adjacent, even considering its oddities and incompatibilities, and you can make it do many of the things a full-size Eight can. We'll take this basic unit, convert the floppy drives to solid state, tap the video output, and put it through its paces.
The Last Evolution, by John W Campbell Jr. (1932)
The Project Gutenberg EBook of The Last Evolution, by John Wood Campbell This eBook is for the use of anyone anywhere at no cost and with almost no restrictions whatsoever. You may copy it, give it away or re-use it under the terms of the Project Gutenberg License included with this eBook or online at www.gutenberg.org
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.