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Chinese scientists leave posts after whistle-blower raises alarm over their research

Chinese scientists leave posts after whistle-blower raises alarm over their research The trio faced heightened scrutiny after a former doctoral student and blogger known as Student Geng raised questions about their work Nankai University in Tianjin announced on Saturday that Chen Quan had been removed as dean of its College of Life Sciences. The university said that Chen, as a corresponding author, failed to properly oversee the quality and authenticity of experimental data in a paper...

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Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.

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