Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

Nature Wednesday 03 June 2026, 00:00 UTC By Carl A. Anderson 1 min read

Key Points

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10627-zSingle-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-localize with genome-wide association study loci than those identified at the tissue level.

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10627-z

Single-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-localize with genome-wide association study loci than those identified at the tissue level.

Nature (ORG) doi:10.1038 (ORG)

Originally published by Nature Read original →

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Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

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