Live Roundups Editor's Desk Insights Executive Ops Weather About 🔍
Home › World News › CFB top 25 betting lines: Texas favored at Tennessee;...
World News

CFB top 25 betting lines: Texas favored at Tennessee; Oregon favored at USC

ESPN Monday 21 September 2026, 14:32 UTC By ESPN 7 min read
Key Points

No. 1 Texas faces its next big challenge of the season on Saturday, playing at No. 14 Tennessee, and that's just one of many compelling matchups around college football in Week 4. No. 4 Ole Miss hits the road for a big game at No. 21 Florida. No. 10 LSU looks to rebound from the emotional loss to the Rebels on Saturday, facing No. 23

No. 1 Texas faces its next big challenge of the season on Saturday, playing at No. 14 Tennessee, and that's just one of many compelling matchups around college football in Week 4. No. 4 Ole Miss hits the road for a big game at No. 21 Florida. No. 10 LSU looks to rebound from the emotional loss to the Rebels on Saturday, facing No. 23 Texas A&M in Baton Rouge. No. 18 Michigan welcomes No. 17 Iowa to the Big House. And No. 20 Oregon heads to Los Angeles to face No. 12 USC. Here are the lines for all the games involving teams in the top 25. All times Eastern. Odds by DraftKings and subject to change. Northwestern at No. 5 Indiana -21 Friday, 8 p.m., FOX Records: Northwestern 2-0, 0-0 vs. AP Top 25; Indiana 3-0, 0-0 vs. AP Top 25 Line Movement Alert: Opened Indiana -23.5, O/U 47.5 Money line: Northwestern (+950); Indiana (-1650) Over/Under: 49.5 (O -115, U -105) FPI Projection Indiana by 18.3 points with a 90% probability to win game outright No. 1 Texas -3.5 at No. 14 Tennessee Saturday, Noon, ABC Records: Texas 3-0, 1-0 vs. AP Top 25; Tennessee 3-0, 0-0 vs. AP Top 25 Line Movement Alert: Opened Texas -7, O/U 56.5 Money line: Texas (-185); Tennessee (+154) Over/Under: 56.5 (O -108, U -112) FPI Projection Texas by 7.2 points with a 70% probability to win game outright Illinois at No. 7 Ohio State -27.5 Saturday, Noon, FOX Records: Illinois 2-1, 0-0 vs. AP Top 25; Ohio State 2-1, 0-1 vs. AP Top 25 Opening Line: Ohio State -27.5, O/U 54.5 Money line: Illinois (+1600); Ohio State (-4000) Over/Under: 53.5 (O -112, U -108) FPI Projection Ohio State by 25.6 points with a 95% probability to win game outright Idaho at No. 11 Texas Tech -35.5 Saturday, Noon, TNT Records: Sam Houston 1-2, 0-0 vs. AP Top 25; Texas Tech 3-0, 1-0 vs. AP Top 25 Opening Line: Texas Tech -37.5, O/U 54.5 Money line: Sam Houston (+--); Texas Tech (+--) Over/Under: 54.5 (O -115, U -105) FPI Projection Texas Tech by 28.6 points with a 97% probability to win game outright Wake Forest at No. 16 Louisville -12.5 Saturday, Noon, ESPN Records: Wake Forest 2-1, 0-1 vs. AP Top 25; Louisville 2-1, 1-1 vs. AP Top 25 Opening Line: Louisville -13.5, O/U 58.5 Money line: Wake Forest (+380); Louisville (-500) Over/Under: 58.5 (O -105, U -115) FPI Projection Louisville by 11.9 points with a 80% probability to win game outright No. 3 Notre Dame -27.5 at Purdue Saturday, 2 p.m., Peacock Records: Notre Dame 3-0, 0-0 vs. AP Top 25; Purdue 1-2, 0-0 vs. AP Top 25 Opening Line: Notre Dame -27.5, O/U 56.5 Money line: Notre Dame (-3600); Purdue (+1500) Over/Under: 57.5 (O -112, U -108) FPI Projection Notre Dame by 27.9 points with a 96% probability to win game outright Oklahoma at No. 2 Georgia -14 Saturday, 3:30 p.m., ESPN Records: Oklahoma 2-1, 0-0 vs. AP Top 25; Georgia 3-0, 0-0 vs. AP Top 25 Line Movement Alert: Opened Georgia -10, O/U 52.5 Money line: Oklahoma (+455); Georgia (-625) Over/Under: 43.5 (O -110, U -110) FPI Projection Georgia by 13.8 points with a 83% probability to win game outright No. 4 Ole Miss at No. 21 Florida -3 Saturday, 3:30 p.m., ABC Records: Ole Miss 3-0, 2-0 vs. AP Top 25; Florida 3-0, 0-0 vs. AP Top 25 Opening Line: Florida -1.5, O/U 57.5 Money line: Ole Miss (+136); Florida (-162) Over/Under: 60.5 (O -115, U -105) FPI Projection Florida by 1.1 points with a 53% probability to win game outright No. 15 Utah -7.5 at Iowa State Saturday, 3:30 p.m., FOX Records: Utah 3-0, 0-0 vs. AP Top 25; Iowa State 2-1, 0-1 vs. AP Top 25 Line Movement Alert: Opened Utah -11.5, O/U 49.5 Money line: Utah (-360); Iowa State (+285) Over/Under: 49.5 (O -105, U -115) FPI Projection Utah by 9.8 points with a 76% probability to win game outright No. 17 Iowa at No. 18 Michigan -4.5 Saturday, 3:30 p.m., CBS Records: Iowa 3-0, 0-0 vs. AP Top 25; Michigan 3-0, 1-0 vs. AP Top 25 Opening Line: Michigan -4.5, O/U 39.5 Money line: Iowa (+170); Michigan (-205) Over/Under: 38.5 (O -108, U -112) FPI Projection Michigan by 5.3 points with a 65% probability to win game outright No. 25 Houston -17.5 at Georgia Southern Saturday, 4 p.m., ESPNU Records: Houston 2-1, 0-1 vs. AP Top 25; Georgia Southern 1-2, 0-0 vs. AP Top 25 Opening Line: Houston -19.5, O/U 55.5 Money line: Houston (-950); Georgia Southern (+625) Over/Under: 54.5 (O -120, U 100) FPI Projection Houston by 16.9 points with a 88% probability to win game outright Wisconsin at No. 13 Penn State -10 Saturday, 5 p.m., Peacock Records: Wisconsin 2-1, 0-1 vs. AP Top 25; Penn State 3-0, 0-0 vs. AP Top 25 Opening Line: Penn State -11.5, O/U 42.5 Money line: Wisconsin (+295); Penn State (-375) Over/Under: 45.5 (O -112, U -108) FPI Projection Penn State by 16.7 points with a 88% probability to win game outright Central Michigan at No. 6 Miami -41.5 Saturday, 6:30 p.m., CW Records: Central Michigan 2-1, 0-0 vs. AP Top 25; Miami 3-0, 0-0 vs. AP Top 25 Opening Line: Miami -42.5, O/U 54.5 Money line: Central Michigan (+--); Miami (+--) Over/Under: 53.5 (O -110, U -110) FPI Projection Miami by 45.7 points with a >99% probability to win game outright South Carolina at No. 8 Alabama -13.5 Saturday, 7 p.m., ESPN Records: South Carolina 2-1, 0-0 vs. AP Top 25; Alabama 3-0, 0-0 vs. AP Top 25 Opening Line: Alabama -11.5, O/U 46.5 Money line: South Carolina (+400); Alabama (-535) Over/Under: 54.5 (O -115, U -105) FPI Projection Alabama by 13 points with a 82% probability to win game outright No. 23 Texas A&M at No. 10 LSU -9.5 Saturday, 7:30 p.m., ABC Records: Texas A&M 2-1, 0-0 vs. AP Top 25; LSU 2-1, 0-1 vs. AP Top 25 Line Movement Alert: Opened LSU -3, O/U 57.5 Money line: Texas A&M (+300); LSU (-380) Over/Under: 52.5 (O -112, U -108) FPI Projection LSU by 4.5 points with a 63% probability to win game outright No. 20 Oregon -3 at No. 12 USC Saturday, 7:30 p.m., NBC Records: Oregon 2-1, 0-0 vs. AP Top 25; USC 4-0, 0-0 vs. AP Top 25 Line Movement Alert: Opened Oregon -5.5, O/U 58.5 Money line: Oregon (-142); USC (+120) Over/Under: 62.5 (O -108, U -112) FPI Projection Oregon by 1.4 points with a 54% probability to win game outright No. 19 Missouri at No. 24 Mississippi State -6 Saturday, 7:45 p.m., SEC Network Records: Missouri 3-0, 0-0 vs. AP Top 25; Mississippi State 3-0, 0-0 vs. AP Top 25 Line Movement Alert: Opened Mississippi State -1.5, O/U 56.5 Money line: Missouri (+170); Mississippi State (-205) Over/Under: 59.5 (O -105, U -115) FPI Projection Mississippi State by 6.2 points with a 67% probability to win game outright Missouri State at No. 22 SMU -34.5 Saturday, 9 p.m., ACC Network Records: Missouri State 1-2, 0-1 vs. AP Top 25; SMU 2-1, 0-1 vs. AP Top 25 Opening Line: SMU -34.5, O/U 59.5 Money line: Missouri State (+3000); SMU (-10000) Over/Under: 58.5 (O -108, U -112) FPI Projection SMU by 29.4 points with a 97% probability to win game outright
CFB (ORG) Texas (LOCATION) Tennessee (LOCATION) Oregon (LOCATION) USC No (ORG) Florida (LOCATION) LSU (ORG) Rebels (LOCATION) Texas A&M (ORG) Baton Rouge (LOCATION) Michigan (LOCATION) Iowa (LOCATION) the Big House (ORG) Los Angeles (LOCATION) USC (ORG)
Originally published by ESPN Read original →

Related Stories

Trump and Xi Meet Amid an Uneasy U.S.-China Trade Truce

President Trump and Xi Jinping, the leader of China, met last year in Busan, South Korea.

NYT Business 16m ago

Belgium's Aikido launches cybersecurity AI model as demand for local tools grows

Belgium's Aikido launches cybersecurity AI model as demand for local tools grows Sept 21 : Belgian cybersecurity firm Aikido on Monday released an open-weight artificial intelligence model designed for cybersecurity applications, seeking to help companies use AI security tools without sending sensitive code to external providers. Rising concern over criminals using AI to identify and exploit software vulnerabilities has fuelled demand for defensive AI tools that can be run locally.

Channel News Asia 20m ago

Pocognoli Facetime helps Miller over summer of discontent

Lennon Miller was Facetimed by new Scotland head coach Sebastien Pocognoli as he returns to the international fold.

BBC Scotland 23m ago

Teenage shuttler first athlete suspended after positive dope test at Asian Games 2026

Teenage Thai badminton player Pitchamon Opatniputh has become the first athlete to be provisionally suspended from the Asian Games 2026 after testing positive for a banned substance, the International Testing Agency (ITA) said on Monday. The 19-year-old, ranked 18th in the world in women's singles by the Badminton World Federation, returned a positive test for furosemide, a prohibited diuretic. The sample was collected during an out-of-competition test in Nagoya on September 17, two days...

Times of India 23m ago