NFL: Odds, spreads, totals and FPI predictions

The Denver Broncos upset the Seattle Seahawks on Thursday to get Week 6 underway. The defending champion Seahawks entered as 2.5-point favorites but fell 17-14 in overtime. Kicking off Sunday's play is an AFC South matchup between the Houston Texans and Jacksonville Jaguars in London (9:30 a.m. ET start). The Los Angeles Rams are the biggest favorite of the week, laying 12.5 points at home versus the Arizona Cardinals. The total for the game is 51.5, one of five games with a total over 50. The Dallas Cowboys, coming off a loss to the previously winless Tampa Bay Buccaneers, head to Lambeau Field to take on the Green Bay Packers on Sunday night, and the San Francisco 49ers host the Washington Commanders on "Monday Night Football" (8:15 p.m. ET on ESPN/ABC) to close out the week. The Cincinnati Bengals, Detroit Lions, Miami Dolphins and Minnesota Vikings are on bye. Here's a look at the odds for every game this week. (You can find early bets we like here.) Note: Odds by DraftKings and subject to change. All times Eastern. Jump to: SEA-DEN | HOU-JAX | CHI-ATL | TEN-IND CAR-PHI | NYJ-NE | BAL-CLE | NO-NYG PIT-TB | ARI-LAR | BUF-LV | LAC-KC DAL-GB | WSH-SF Houston Texans vs. Jacksonville Jaguars -2.5 Sunday, 9:30 a.m., NFL Net Moneyline: Texans (+124); JAGUARS (-148) Total: 42.5; Opened: 41.5 FPI favorite: Jaguars by 2.3 with a 59% probability to win the game outright Chicago Bears -1.5 vs. Atlanta Falcons Sunday, 1 p.m., Fox Moneyline: Bears (-118); Falcons (-102) Total: 51.5; Opened: 47.5 FPI favorite: Bears by 2.9 with a 61% probability to win the game outright Check out the latest Super Bowl odds and major NFL awards futures. Tennessee Titans vs. Indianapolis Colts -7 Sunday, 1 p.m., Fox Moneyline: Titans (+280); Colts (-355) Total: 44.5; Opened: 48.5 FPI favorite: Colts by 6.1 with a 72% probability to win the game outright Carolina Panthers -3.5 vs. Philadelphia Eagles Sunday, 1 p.m., CBS Moneyline: Panthers (-185); Eagles (+154) Total: 38.5; Opened: 43.5 FPI favorite: Panthers by 2 with a 58% probability to win the game outright New York Jets vs. New England Patriots -7.5 Sunday, 1 p.m., CBS Moneyline: Jets (+275); Patriots (-345) Total: 43.5; Opened: 42.5 FPI favorite: Patriots by 8.3 with a 80% probability to win the game outright Baltimore Ravens -3.5 vs. Cleveland Browns Sunday, 1 p.m., Fox Moneyline: Ravens (-205); Browns (+170) Total: 40.5; Opened: 44.5 FPI favorite: Ravens by 4.4 with a 66% probability to win the game outright New Orleans Saints -1.5 vs. New York Giants Sunday, 1 p.m., Fox Moneyline: Saints (-112); Giants (-108) Total: 45.5; Opened: 45.5 FPI favorite: Saints by 1.3 with a 55% probability to win the game outright Pittsburgh Steelers -2.5 vs. Tampa Bay Buccaneers Sunday, 1 p.m., CBS Moneyline: Steelers (-148); Buccaneers (+124) Total: 39.5; Opened: 45.5 FPI favorite: Steelers by 2.3 with a 59% probability to win the game outright Arizona Cardinals vs. Los Angeles Rams -12.5 Sunday, 4:05 p.m., Fox Moneyline: Cardinals (+575); Rams (-850) Total: 51.5; Opened: 46.5 FPI favorite: Rams by 11.9 with a 87% probability to win the game outright Buffalo Bills -4.5 vs. Las Vegas Raiders Sunday, 4:25 p.m., CBS Moneyline: Bills (-205); Raiders (+170) Total: 53.5; Opened: 47.5 FPI favorite: Bills by 6.1 with a 72% probability to win the game outright Los Angeles Chargers vs. Kansas City Chiefs -7.5 Sunday, 4:25 p.m., CBS Moneyline: Chargers (+360); Chiefs (-470) Total: 41.5; Opened: 46.5 FPI favorite: Chiefs by 6.7 with a 75% probability to win the game outright Dallas Cowboys vs. Green Bay Packers -1.5 Sunday, 8:20 p.m., NBC Moneyline: Cowboys (+100); Packers (-120) Total: 53.5; Opened: 51.5 FPI favorite: Cowboys by 0.6 with a 52% probability to win the game outright Washington Commanders vs. San Francisco 49ers -7.5 Monday, 8:15 p.m., ESPN, ABC Moneyline: Commanders (+330); 49ers (-425) Total: 51.5; Opened: 50.5 FPI favorite: 49ers by 11.3 with a 86% probability to win the game outright Thursday's result Seattle Seahawks -2.5 vs. Denver Broncos Thursday, 8:15 p.m., Prime Video Moneyline: Seahawks (-142); Broncos (+120) Total: 40.5; Opened: 43.5 FPI favorite: Seahawks by 0.7 with a 53% probability to win the game outright