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Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Court orders Flipkart to pay Rs 1.51 lakh for delivering wrong air purifier model
The District Consumer Disputes Redressal Commission, Adilabad in Telangana has held Flipkart and its seller jointly liable for deficiency in service and unfair trade practice after a customer received a different air purifier model than the one he had ordered. The court ordered both opposite parties — Flipkart Internet Private Limited and Consulting Rooms Private Limited — to refund Rs 8,398 with 12 per cent interest and pay Rs 1.51 lakh as compensation along with Rs 7,000 towards litigation...
Spain defeat causes sleepless night as Wiegman seeks reaction from Lionesses
England Women: Sarina Wiegman looking for Lionesses to show their true selves as Lauren Hemp admits to sleepless night after Spain thrashing Lauren Hemp said she and some of her team-mates couldn't sleep after England lost 4-0 to Spain on Friday; the defeat was their worst since 2009 and has left World Cup qualification out of their hands; England face Ukraine on Tuesday in their final World Cup qualifier Monday 8 June 2026 12:34, UK Sarina Wiegman is looking for a response from her England...
McIlroy finds 'good stuff' ahead of US Open but identifies 'limited' area
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India record biggest Test win vs Afghanistan as debutant takes seven wickets
India record their largest Test victory against Afghanistan as debutant Manav Suthar takes seven wickets India made history on Monday as Shubman Gill's side recorded their largest-ever Test victory, beating Afghanistan by an innings and 300 runs inside three days, as debutant Manav Suthar took seven wickets Monday 8 June 2026 13:12, UK Manav Suthar took seven wickets on debut to spur India to their largest Test victory, defeating Afghanistan by an innings and 300 runs in three days in New...
Crossbench MPs demand answers from Tasmanian premier, issue ultimatum
Tasmanian MPs push premier for answers about Madeleine Ogilvie Mon 8 Jun 2026 at 12:14pm In short: Four Tasmanian Greens MPs and three independent MPs have written to Premier Jeremy Rockliff asking a series of questions relating to Madeleine Ogilvie's resignation from cabinet. Ms Ogilvie resigned just over a week ago following allegations she misled parliament. The crossbench MPs say if direct and exact answers to their questions are not forthcoming they "reserve the right to use the...
Suppression order extended for name of high-profile Qld man in extortion case
Magistrate extends order to suppress name of high-profile Queensland man at centre of extortion case Mon 8 Jun 2026 at 12:29pm A magistrate has extended a non-publication order preventing the identification of a high-profile Queensland man at the centre of an alleged extortion threat. The Cairns Magistrates Court has heard an accused man, who cannot be named, threatened to expose an alleged affair his former partner had with the married high-profile Queenslander in 2017. The woman was...
Family loses everything as large fire destroys house
Fire sparked on porch engulfs and destroys Warilla home Mon 8 Jun 2026 at 12:58pm In short: A house in Warilla was engulfed within minutes after a fire appears to have spread from outdoor furniture to the roof. Firefighters worked on the blaze for hours, saying it was a "complex" job due to fallen powerlines and a venting gas cylinder. The house was destroyed and the community is rallying behind the impacted family.
Korda pips Hull to major glory in US Women's Open thriller
US Women's Open: Nelly Korda claims thrilling victory as Charley Hull narrowly misses out on major win in California Nelly Korda finished a shot ahead of Charley Hull and Gaby Lopez at the US Women's Open; Korda's win is her fourth major title and second of the season; Hull briefly led on the final day but has to settle for fifth major runner-up finish Monday 8 June 2026 01:12, UK World No 1 Nelly Korda snatched a dramatic victory at the US Women's Open as Charley Hull's wait for an elusive...
'What a legacy': Pioneering researcher Richard Scolyer dies aged 59
Professor Richard Scolyer dies aged 59 leaving behind legacy of revolutionary brain cancer research Mon 8 Jun 2026 at 12:06am Former Australian of the Year Professor Richard Scolyer has died aged 59 after fighting the "worst of the worst brain cancers". His legacy: fast-tracking revolutionary cancer treatment by volunteering to be "patient zero" in a radical approach to treating his tumour. Scolyer fought the aggressive brain cancer for almost three years, defying the terrible survival odds.