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D - ESP, a series of E Squared Investment Fund, LLC (0002134091) (Filer)
Filed: 2026-06-03 AccNo: 0002134091-26-000004 Size: 6 KB Item 3C: Investment Company Act Section 3(c) Item 3C.1: Section 3(c)(1)
A Parameterized Algorithm for Testing whether the Limit of a Diagram is Empty
Announce Type: cross Abstract: A limit of a (small) diagram $d : J \to E$ in a complete category $E$ can be thought of as specifying a set of equations involving the objects of $E$. To motivate this intuitively, one can think of each object $d(j)$ as a "variable" and each morphism in $J$ as a "constraint" connecting these variables. If $E$ has an initial object, a natural question arises: does our set of equations have any solution at all? Equivalently, we can ask: is the limit of $d$ initial?
A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone
Abstract Whale falls are biodiversity oases at seabeds1,2,3,4,5,6, yet their record from the oceans has remained sparse and fragmentary6,7. Here we report the discovery of a vast whale necropolis in the Diamantina Zone (4,616- to 7,001-m depth), extending about 1,200 km along the sea floor of the southeastern Indian Ocean. This area has a deep and extensive accumulation comprising five modern natural whale-fall communities and 476 fossil cetaceans recorded.
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
Breaking the Cascade: Compact Nonlinear Optical Computing with Single-Layer Encoder-Decoder Co-Localization
Announce Type: new Abstract: We demonstrate that nonlinear computing can be achieved with a single linear diffractive surface under coherent illumination. We introduce a compact encoder-decoder co-localization (E+D) architecture in which an input-dependent dynamic encoder and a static optimized decoder are integrated within the same phase-only diffractive plane. Following free-space propagation, coherent interference between the encoder and decoder fields, combined with intensity detection,...
Breaking the Cascade: Compact Nonlinear Optical Computing with Single-Layer Encoder-Decoder Co-Localization
Announce Type: cross Abstract: We demonstrate that nonlinear computing can be achieved with a single linear diffractive surface under coherent illumination. We introduce a compact encoder-decoder co-localization (E+D) architecture in which an input-dependent dynamic encoder and a static optimized decoder are integrated within the same phase-only diffractive plane. Following free-space propagation, coherent interference between the encoder and decoder fields, combined with intensity...
A thalamus–brainstem attractor network drives history-biased decisions
Abstract Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial dependence1,2,3. Large-scale recordings during behaviour have identified that serial dependence is a common motif for decision-making, with neural representations of past experiences found throughout the brain4,5,6,7,8,9,10,11. However, it remains unclear whether this bias arises from dedicated neural circuits with history-specific...
Empirical Approximation of $L_p$ Norms
arXiv:2606.00347v1 Announce Type: cross Abstract: We study empirical $L_p$ moments of a random vector $\pmb\varphi$ based on its i.i.d.\ copies $\pmb\varphi^1,\ldots,\pmb\varphi^m$, that is, $\frac1m\sum_{j=1}^m |\langle \pmb\varphi^j,y\rangle|^p$. Our main result is a new estimate for the expected uniform deviation \[ \mathbb{E}\sup_{y\in D}\biggl| \frac1m\sum_{j=1}^m |\langle \pmb\varphi^j,y\rangle|^p -\mathbb{E}|\langle \pmb\varphi,y\rangle|^p \biggr| \] over an arbitrary index set $D$....
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.