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Why the U.S.-Iran Negotiations Are Taking So Long

new video loaded: Why the U.S.-Iran Negotiations Are Taking So Long Why the U.S.-Iran Negotiations Are Taking So Long As negotiations to end the war in Iran drag on, our reporter David E. Sanger describes the factors that are complicating any agreement. By David E. Sanger, Alexandra Ostasiewicz, Nikolay Nikolov, Rafaela Balster, Ray Whitehouse, Jon Miller and Stephanie Swart June 2, 2026 Watch

New York Times 7d ago

Predicting every game of the entire World Cup: All...

Everyone is using artificial intelligence to do, well, everything. With the World Cup starting on June 11, you can't scroll for more than a couple of minutes without hitting another post or video or reel of someone telling you how they used AI to predict the World Cup. So, I decided to use my own supercomputer to predict every game of the 2026 World Cup -- the supercomputer is called "my brain."

ESPN 5d ago

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.

Nature 17h ago

Everything you need to know about Curacao - the World Cup's smallest ever nation

World Cup 2026: All you need to know about Dick Advocaat's Curacao - the tournament's smallest ever nation Legendary Dutch manager Dick Advocaat will lead Curacao into their first ever World Cup; 'The Blue Wave' are the smallest ever nation to reach the tournament; many of their players play or have played in the UK including Juninho and Leandro Bacuna, Tahith Chong and Ar'jany Martha Saturday 6 June 2026 22:35, UK On Tuesday November 18 2025, Curacao travelled to Kingston to take on Jamaica...

Sky Sports Football 2d ago

Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6

Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.

Nature 17h ago

WNBA Power Rankings: Welcome to the top 2, Dallas

A year ago on this date, the Dallas Wings were 1-9. They would not get to double-digit victories until the last day of the season, Sept. 11, when they finished 10-34. After trudging through that victory desert, 2026 has been like an oasis.

ESPN 1d ago

World Cup Rank: The 50 best players in the 2026 to...

As silly as it might seem, whoever wins the 2026 World Cup is going to have an outsize impact on who the soccer world decides is the best soccer player in the world. Sure, there are 11 players on each team. And OK, fine, the best players have possession of the ball for only about three total minutes every match.

ESPN 2d ago

A thalamus–brainstem attractor network drives history-biased decisions

Abstract Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial dependence1,2,3. Large-scale recordings during behaviour have identified that serial dependence is a common motif for decision-making, with neural representations of past experiences found throughout the brain4,5,6,7,8,9,10,11. However, it remains unclear whether this bias arises from dedicated neural circuits with history-specific...

Nature 17h ago

A prognostic human brain network for diffuse midline glioma

Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.

Nature 17h ago

Avian Visitors

Avian Visitors I was initally planning on leaving this as a ‘true’ personal project of sorts. I love a good project writeup of course, but frankly I thought this was too quick an afternoon project to warrant any more documentation than a tweet. Twitter thought otherwise … i mounted a tiny microphone on my apartment balcony to listen for any birds passing by and built a site to collage them as they're heard pic.twitter.com/85KrLRL5tu —

Hacker News 10d ago