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Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
A peculiar peace prize, sky-high tickets, threatened boycotts. The rocky road to the World Cup
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Frankie Valli, 92, abruptly cancels remainder of Four Seasons farewell tour to focus on his health
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'Unchosen' LA Knight may finally be back on the path of WWE glory after King of the Ring shocker
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Washington Nationals apologize to pitcher after firing director who admitted to religious discrimination
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Zhang Linghe, Dylan Wang, Xiao Zhan: 8 Chinese period drama actors fans can't get enough of
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Are Ronaldo, Messi still the largest World Cup draws, or is Mbappe bigger?
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What exactly are the Savannah Bananas becoming?
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What exactly are the Savannah Bananas becoming?
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