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A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Predicting every game of the entire World Cup: All...
Everyone is using artificial intelligence to do, well, everything. With the World Cup starting on June 11, you can't scroll for more than a couple of minutes without hitting another post or video or reel of someone telling you how they used AI to predict the World Cup. So, I decided to use my own supercomputer to predict every game of the 2026 World Cup -- the supercomputer is called "my brain."
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Ranking college football's top 100 newcomers for t...
If the upcoming 2026 college football season is anything like its predecessor, transfer quarterbacks and top freshmen will be crucial for many College Football Playoff runs. And by now, with less than 100 days until the start of the season, we can assess rosters and what players did during spring practice with their new teams. While we have analyzed the top newcomer for each Power 4 team, these rankings are regardless of teams.