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Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease
CLN3 disease, the most common form of the Neuronal Ceroid Lipofuscinoses (NCLs), causes progressive cognitive decline and language impairment in humans. A pathological hallmark is the accumulation of storage material within neuronal lysosomes resulting from mutations in the CLN3 gene. We previously identified parallel deficits in auditory duration mismatch negativity (MMN), an electroencephalography (EEG)-based marker of auditory change detection, in individuals with CLN3 disease and in...
Information Rate Decomposition for Noisy Nanopore Channels with Geometric Duplication
arXiv:2606.06808v1 Announce Type: new Abstract: This paper studies information rates of noisy duplication channels with memory, motivated by nanopore DNA sequencing. In nanopore sequencing, the measured signal is affected by both inter-symbol interference (ISI), caused by multiple DNA bases residing in the pore, and random sample duplications, where variable translocation speed causes each base to generate a random number of samples.