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Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
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I will be a Groupon stan until I die. I have used their coupons for massages, haircuts, oil changes, and for experiences like a Camel ride in the Sahara while I was in Morocco and a deal on glamping in an Airstream trailer in Joshua Tree. Groupon is one of the best ways to get reduced prices on something you’ve always wanted to try, but don’t want to pay full price for.
Will Gen Z be the generation to revive moviegoing?
Hollywood can breathe a sigh of relief: Generation Z is not only going to the movies, it's driving box office growth. During the pandemic, when theaters shut down and streaming became a dominant force in the media landscape, fears rose that this young cohort would shun the big screen as they matured into more engaged consumers. However, this generation, which ranges from around 14 to 29 years old, is one of the most active moviegoing demographics and attends more films per year than some...