AMN

CytoGem-XAI:A Hypergraph Neural Network Framework for Genome-Scale Metabolic Modeling and Interpretable Analysis

Genome-scale metabolic models are essential for understanding cellular metabolism, yet existing deep learning approaches remain black boxes, and traditional flux balance analysis (FBA) cannot provide sample-specific predictions. To our knowledge, CytoGem-XAI is the first framework to combine hypergraph neural network representation with interpretable, FBA-parallel analysis and sample-specific metabolic characterization. Built upon hypergraph representations where reactions are encoded as...