Acinetobacter
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Related Articles from SNS
Study reveals hidden gut factor that may make some people more susceptible to sepsis
Potentially deadly sepsis may be more likely in certain patients due to problems in the gut. Researchers from the Korea Research Institute of Bioscience and Biotechnology's Infectious Disease Research Center used female mouse models to investigate why sepsis outcomes can vary so dramatically. The study, published in the journal Nature, looked at genetically similar mice with different gut microbiomes.
Dual-Chassis Strategy for Bridging Adaptive Evolution and Rational Design for Synthetic Biology
Genome streamlining and pathway refactoring are powerful strategies for constructing controllable microbial chassis for both fundamental studies and applications. While rational design benefits from reduced genetic complexity, adaptive laboratory evolution (ALE) thrives on metabolic redundancy, creating a mismatch between optimal hosts for design and evolution. Here, we introduce a dual chassis framework (DUET) in which rational pathway construction and adaptive evolution are first carried...
Fusion of a non-specific DNA-binding domain enhances Cas12a trans-cleavage for robust nucleic-acid diagnostics
CRISPR-Cas12a underlies powerful genome-editing and nucleic-acid detection technologies, yet its performance is limited by inefficient target engagement and low catalytic turnover, particularly at low target abundance and elevated temperatures. Here, we report a modular protein-engineering strategy to enhance Cas12a trans-activity by fusing the hyperthermophilic DNA-binding protein Sso7d to the N terminus of Lachnospiraceae bacterium ND2006 Cas12a (LbaCas12a). The resulting fusion enzyme...
Variable zinc concentrations among commercially available Mueller-Hinton Broth brands affects SIR interpretations during broth microdilution in vitro antimicrobial susceptibility testing with the novel metallo-beta-lactamase inhibitor APC148
The well-known discrepancy between the in vitro and in vivo efficacy of {beta}-lactam antibiotics in metallo-{beta}-lactamase (MBL) containing Gram-negative bacteria has during recent years been found to be at least partially explained by zinc levels at infection sites being much lower than those found in conventional cation-adjusted Mueller-Hinton Broth (caMHB) media used for in vitro susceptibility testing. Previous studies have also demonstrated that a high variability exists with respect...