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Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery to lymph nodes enhance humoral immune responses
Technologies that simplify complex dosing regimens as single-shot immunizations may be important for vaccines against difficult to neutralize pathogens. Here we characterized delivery mechanism of clinically-relevant HIV vaccine immunogens using core-shell microparticles comprising immunogen formulations spray-dried to form solid spherical microparticles and subsequently coated with a nanoscopic alumina shell using atomic layer deposition (ALD). ALD particles exhibited a time delay in...
Integrated multi-omics reveals adaptive anti-oxidant remodeling in early alcohol-associated liver disease
Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality. Although various omics approaches have revealed early metabolic alterations, individual datasets provide limited mechanistic insight. Here, we integrated RNA sequencing with mass spectrometry-based analyses to quantify gene expression, protein abundance, proteome and acetylome dynamics, and metabolic fluxes in livers of alcohol-fed mice.
'Major shake-up': Councillors circle top spot as lord mayor bows out
Who could replace Hobart's outgoing lord mayor Anna Reynolds? Thu 4 Jun 2026 at 5:10am In short: Lord Mayor Anna Reynolds will not seek re-election, opening the race for Hobart's top local government role. Multiple elected members have already voiced their hopes to succeed her, promising to heal a chamber that some describe as "toxic".
Walgreens didn’t abandon Chicago’s South Side. We let crime drive them out
Walgreens didn’t leave the South Side of Chicago because they hate Black people. They left because we made it impossible for them to stay. Just recently, another Walgreens shut down on Cottage Grove, and once again the public conversation turned in the wrong direction.