ApoB
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Related Articles from SNS
The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion
Background: Decreased hepatic removal of low density lipoproteins (LDL) and increased apolipoprotein B (apoB) production cause hypercholesterolemia, a major causal risk factor of atherosclerotic cardiovascular disease (ASCVD). By a genome-wide siRNA screen, we previously identified subunits of the Coat protein I (COPI) complex to limit LDL uptake into Huh-7 hepatocarcinoma cells. Methods: These findings were validated by targeted in vitro experiments as well as genetic association studies in...
Scientists discover hidden liver switch that cuts harmful cholesterol
Scientists at UT Southwestern have uncovered a surprising new “master switch” that helps control how much cholesterol the liver sends into the bloodstream. The newly identified protein, HELZ2, works by shutting down the genetic instructions needed to produce apoB — a key building block of the cholesterol-carrying particles linked to clogged arteries and heart disease.
Doctor reveals 4 health markers that may predict heart attack and stroke risk
For decades, LDL cholesterol has been one of the most talked-about numbers in heart health. Often called the "bad cholesterol," elevated LDL levels have been linked to the buildup of fatty plaques inside arteries, a process known as atherosclerosis. Over time, these plaques can narrow or block blood vessels supplying the heart and brain, increasing the risk of heart attacks and strokes.