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Auranofin potentiates cisplatin response through context-dependent NOTCH-associated signaling states in endometrial cancer
Therapeutic resistance remains a major challenge in advanced and recurrent endometrial cancer (EC). Aberrant NOTCH signaling has been associated with aggressive tumor behavior and therapeutic resistance across multiple malignancies, yet its therapeutic significance in EC remains incompletely defined. We investigated whether auranofin (AuR), a noncanonical modulator of NOTCH signaling through the transcriptional effector RBPJ, alters platinum responsiveness in EC models.
Bobby Deol recalls family’s financial struggles and Dharmendra’s sacrifices
The year 2023 turned out to be a landmark year for the Deol family, filled with celebrations and major career milestones. Veteran actor Dharmendra won everyone over with his heartwarming performance in ‘Rocky Aur Rani Kii Prem Kahaani’, while Sunny Deol took the box office by storm with the massive blockbuster ‘Gadar 2’. Bobby Deol, on the other hand, made a striking comeback with ‘Animal’, reminding everyone of his acting prowess.
'Panchayat' Season 5 star Chandan Roy aka Vikas decodes Phulera’s next chapter
Fans have been eagerly waiting for Season 5 of Prime Video’s blockbuster series ‘Panchayat’. Now, actor Chandan Roy, who plays the beloved character Vikas, has dropped an exciting hint about the upcoming season that is sure to raise anticipation among viewers. The audience's favorite fictional village, Phulera, is gearing up to return with more entertaining stories.
'I had Rs 84 in my account and would bow to the bank every day': Gaurav Gera on struggles
Actor-comedian Gaurav Gera is currently enjoying the love coming his way following the success of Dhurandhar and Dhurandhar: The Revenge. But the journey to this moment was far from easy. In a recent conversation, Gaurav opened up about his struggles, career choices, financial hardships and the lessons that have kept him grounded.
More about Neelam Kothari’s family bungalow in Lonavala
Neelam Kothari, an icon from the early 90s cinema, has quite an extravagant lifestyle. After doing films like ‘Hum Saath Saath Hain’, ‘Antim Nyay’, and many others, she retired from the showbiz, but not all things bling. She became a jewellery designer and soon was able to establish a successful empire.
'Mera sapna teeno format khelne ka hai': Vaibhav Sooryavanshi's clear message
With his fireworks in the IPL, Under-19 World Cup and domestic circuit, young batting sensation Vaibhav Sooryavanshi has earned a place in the senior India side. Sooryavanshi on Saturday received his maiden call-up to India's T20I squad for the tours of Ireland and England, as well as the Asian Games. In the process, he became the youngest player to be picked in the Indian men's team.
Which sparkling water is the best?
The Sparkling Water Report three minds and gullets looking for the winning bubbles With my friends Manuel and Aurélien, also friends of the fizz, we set out to find which sparkling water is the best one. We limited ourselves to ones that you could readily buy in Paris, up to the limit of what we could carry. This means 14 waters, blind tested: each water was poured in an opaque glass associated to a number, the glasses were then shuffled and turned facing opposite of the drinkers.
Film producer and ex-CBFC chief Pahlaj Nihalani passes away due to liver cirrhosis
Veteran film producer and former chairman of the Central Board of Film Certification (CBFC), Pahlaj Nihalani, has passed away today, on June 4, 2026. He was admitted to the Nanavati Hospital in Mumbai. He was diagnosed with liver cirrhosis and had been suffering for the last four months.
Anthropic, please ship an official Claude Desktop for Linux
- Notifications You must be signed in to change notification settings - Fork 21.2k Official Claude Desktop build for Linux (Ubuntu LTS / Debian) #65697 Description Preflight Checklist - I have searched existing requests and this feature hasn't been requested yet - This is a single feature request (not multiple features) Problem Statement Preflight note. The closest open issue is #40347.
Kangana Ranaut backs Ranveer Singh amid FWICE ban over ‘Don 3’ row
Ranveer Singh and Farhan Akhtar have been at loggerheads ever since his exit from 'Don 3'. The producer-director took the matter to Federation of Western India Cine Employees (FWICE) and the Indian Motion Picture Producers' Association (IMPPA) and they decided to ban the actor. FWICE president BN Tiwari said the union had decided to issue a "non-cooperation directive" against Ranveer, until he agreed to meet its representatives.