Augmented Spatial Transcriptomics Imputation
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SNR-ST-Mix: Sample-specific Neighborhood Regression Mixup for Augmented Spatial Transcriptomics Imputation with Deep Neural Network
arXiv:2606.08712v1 Announce Type: new Abstract: Purpose: Spatial transcriptomics (ST) enables gene expression measurements within the tissue context. However, these measurements are often noisy, low-resolution, and sparsely sampled, which limits the recovery of fine spatial structure.
Cellpin enables reference-based imputation and denoising of spatial transcriptomes
Spatially resolved transcriptomics enables gene expression profiling within tissue architecture, but targeted panels leave much of the transcriptome unmeasured and spatial artifacts such as RNA diffusion and segmentation errors introduce technical noise. These limitations necessitate computational imputation and denoising, yet existing methods typically incorporate spatial measurements during training, limiting scalability and risking the embedding of technology-specific artifacts into...