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TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma
Tyrosine kinase inhibitors (TKIs) are the first-line therapy for chronic myeloid leukemia (CML), yet fail to eliminate quiescent CML cells residing in the bone marrow (BM). While transcriptome adaptation and metabolic rewiring have been recognized as mechanisms enabling CML survival, the contribution of RNA processing, known to expand the repertoire of isoforms and directly mediate therapy resistance in leukemia, is poorly characterized. We previously found that a subset of alternative...
Binary Amplitude Modulation Suppresses Noise Up-Conversion in Coherent Diffractive Optical Networks
arXiv:2605.30820v1 Announce Type: new Abstract: We establish a fundamental principle in coherent wave-optical computing: restricting the modulation manifold from continuous complex-valued to binary amplitude suppresses stochastic-noise up-conversion while preserving classification fidelity, yielding a counter-intuitive less-is-more robustness law. Seven-layer binary-amplitude-mask D2NN (BM-D2NN) achieve 90.9% (MNIST) and 81.9% (Fashion-MNIST) test accuracy, within 2~4 pp of...
ReTabSyn: Realistic Tabular Data Synthesis via Reinforcement Learning
arXiv:2603.10823v2 Announce Type: replace-cross Abstract: Deep generative models can help with data scarcity and privacy by producing synthetic training data, but they struggle in low-data, imbalanced tabular settings to fully learn the complex data distribution. We argue that striving for the full joint distribution could be overkill; for greater data efficiency, models should prioritize learning the conditional distribution $P(y\mid \bm{X})$, as suggested by recent theoretical analysis....
Experimental validation of a fast control-oriented, physics-informed surrogate model for plasma equilibrium reconstruction in the TCV tokamak
arXiv:2606.09487v1 Announce Type: new Abstract: Magnetic equilibrium reconstruction provides the plasma state estimate required for real-time shape control in tokamaks. We present a fast, physics-informed neural network surrogate of the \texttt{liuqe} equilibrium reconstruction code \cite{liuqe1} for the TCV tokamak at EPFL, achieving inference times below 100~$\bm\mu$s and enabling 10~kHz shape control. The model is trained on around 10,000 TCV discharges spanning the full operational range...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Viscous spectral energy coupling across scales in generalised Newtonian fluids
Announce Type: new Abstract: We investigate the spectral energy dynamics of turbulent flows with variable viscosity using direct numerical simulation of homogeneous isotropic turbulence of generalised Newtonian fluids described by the Carreau constitutive model, covering both shear-thinning and shear-thickening regimes. The spectral evolution equations for the variable viscosity Navier-Stokes system show that the viscous term becomes nonlinear and gives rise to a convolution product in...