Background Transcriptional
No mentions found
This entity hasn't been tracked yet, or Iris is still building its knowledge base.
Related Articles from SNS
Genotype and methylation interact to reconfigure transcriptional regulation in colorectal cancer
Background Transcriptional regulation is shaped by both genomic variants and the environment. Yet, how the regulatory effects of genomic variants are reconfigured by dynamic epigenomic changes during tumorigenesis remains incompletely understood. Methods We investigated methylation context-dependent links between genotype and gene expression in colorectal cancer (CRC) using paired tumor and normal-adjacent tissue (NAT) from 80 patients, thereby controlling for germline genomic background.
Single-cell gene regulatory network reconstruction and key regulator identification using a dual-channel fusion graph convolutional network
Background and objective: Gene regulatory networks are formed by complex regulatory relationships between transcription factors and their target genes. A systematic understanding of these regulatory relationships is crucial for deciphering the molecular mechanisms that underlie cell state transitions under physiological and pathological conditions. Single-cell expression data can reveal cell-type-specific transcriptional regulation, and computational methods have recently been developed to...
Show HN: Komi-learn – continuous memory and self-improvement for coding agents
Continuous memory and self-improvement for coding agents. It learns how you work and recalls it automatically, with no commands. Works with Claude Code and Codex.
Samsung Galaxy A37 review: A solid deal even in this economy
Samsung Galaxy A37 review: A solid deal even in this economy With the price of damn near everything going up these days, finding a good deal is harder than ever, especially when you're shopping for electronics. However, after refreshing its midrange phone lineup for 2026, Samsung has a new contender for the best phone under $500 in the Galaxy A37 5G. It's not the fastest or flashiest device around, but for anyone who just wants a solid Android handset for a decent price, this is it.
Stateful Online Monitoring Catches Distributed Agent Attacks
arXiv:2605.31593v1 Announce Type: new Abstract: Language models can find thousands of severe software vulnerabilities, and agents are increasingly being misused for cyberattacks. To avoid detection, attackers frequently distribute their misuse, splitting a harmful task across many user accounts so each individual transcript looks benign. Because safety monitors score only one agent context at a time, they are structurally blind to misuse that is only visible in aggregate, across many accounts.
Comprehensive characterization of skeletal muscle remodeling in hSOD1G93A mice reveals limited functional impact of systemic FOXO1 inhibition
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron (MN) loss, muscle atrophy and paralysis. Although traditionally considered a MN-specific disease, accumulating evidence supports a crucial contribution of skeletal muscle pathology to disease onset and progression. Except for specific mutations, to date there is no effective treatment for ALS.
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
SOX9 regulates endothelial tip cell specification to promote cerebral and neuroretinal vascularization
Background: Tissue vascularization relies on the organotypic specification of endothelial tip cells to interpret local cues and guide angiogenic sprouts into specific tissue compartments. However, the molecular regulators controlling brain and retinal endothelial tip cell identity remain poorly understood. Methods: Endothelial-specific Sox9 loss-of-function mouse was combined with single-cell, spatial, and bulk RNA sequencing analyses of developing mouse brain and retinal vasculature, as...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma
Background and Aims: Intrahepatic cholangiocarcinoma (iCCA) is a tumor type with a high lethality due to late diagnosis and profound resistance to conventional chemotherapy. To date the molecular mechanisms underlying multidrug resistance remain poorly defined. Here, we integrate single-cell transcriptomics, clinicopathological analysis, and functional genomics to elucidate the molecular basis of cisplatin resistance in iCCA.