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Bayesian Experimental Design

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CA-BED: Conversation-Aware Bayesian Experimental Design

new Abstract: Large Language Models (LLMs) excel at static reasoning tasks, yet their performance often degrades in interactive scenarios where information must be actively acquired through questioning. A key challenge lies in selecting questions that reduce uncertainty while incorporating responses that may be ambiguous or only partially informative. To address this, we propose Conversation-Aware Bayesian Experimental Design (CA-BED), an inference-time probabilistic dialog planning...

arXiv CS 8d ago

ShaplEIG: Bayesian Experimental Design for Shapley Value Estimation

arXiv:2606.02247v1 Announce Type: cross Abstract: Shapley values are a principled attribution measure widely used in interpretable machine learning, but their exact computation scales exponentially with the number of players, motivating a wide range of approximation methods based on value function evaluations of sampled coalitions. This raises the question of whether approximation accuracy can be improved by adaptively selecting coalitions for evaluation based on previous evaluations. This...

arXiv CS 8d ago

Multilevel randomized quasi-Monte Carlo estimator for nested integration

arXiv:2412.07723v5 Announce Type: replace Abstract: Nested integration problems arise in various scientific and engineering applications, including Bayesian experimental design, financial risk assessment, and uncertainty quantification. These nested integrals take the form $\int f\left(\int g(\boldsymbol{y},\boldsymbol{x})\mathrm{d}\boldsymbol{x}\right)\mathrm{d}\boldsymbol{y}$, for nonlinear $f$, making them computationally challenging, particularly in high-dimensional settings. Although...

arXiv CS 7d ago

Multi-feature Classification to Improve Colorimetric Loop-Mediated Isothermal Amplification Fidelity

Loop-mediated isothermal amplification (LAMP) is a cost-effective and portable assay technique for performing nucleic acid-based diagnostics in the field whose adoption is hindered by design and reproducibility issues. This is due to a complex primer design process that fine-tunes parameters across 6-8 binding regions. The likelihood of assay success depends on satisfying thermodynamic and secondary structure constraints while maintaining target specificity and avoiding overlaps between...

bioRxiv 2d ago

A prognostic human brain network for diffuse midline glioma

Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.

Nature 20h ago

Learning from Human Driving: A Human-in-the-Loop Online Behavior Cloning Framework for Autonomous Driving

Announce Type: new Abstract: With the evolution of large foundation models (LFMs), data-driven autonomous driving has made significant strides. However, existing paradigms still face severe challenges in complex interaction and long-tail scenarios due to distribution shift and causal confusion. These limitations often result in a lack of human-level decision-making flexibility and safety in extreme conditions.

arXiv CS 1d ago

Bayesian optimisation and graph-based rheology enable sequence-dependent modelling of DNA materials

Bridging molecular and emergent properties is essential for designing soft matter. Synthetic DNA materials are attractive in this context because their sequence design space supports a wide range of material properties. Targeted design of DNA materials is hindered by scale differences and manual exploration of vast design spaces.

bioRxiv 11d ago

Flow Matching Calibration for Simulation-Based Inference under Model Misspecification

arXiv:2509.23385v5 Announce Type: replace-cross Abstract: Simulation-based inference (SBI) is transforming experimental sciences by enabling parameter estimation in complex non-linear models from simulated data. A persistent challenge, however, is model misspecification. In a Bayesian setting, targeting posterior distributions, errors may arise from the simulator, the noise or prior modelling.

arXiv CS 6d ago

Learning Coupled Subspaces for Multi-Condition Spike Data

Announce Type: replace Abstract: In neuroscience, numerous studies conduct sensory or behavioral experiments under multiple conditions to acquire neural responses in the form of high-dimensional spike train datasets. Analyzing high-dimensional spike data is a challenging statistical problem. To this end, Gaussian process factor analysis (GPFA), a popular class of latent variable models, has been proposed for data collected under a single experimental condition.

arXiv CS 9d ago

Improved quantum processor logical error rates via correction and detection

Abstract Performing quantum algorithms for critical problems in physics and chemistry requires substantially lower error rates than the physical error rates of present quantum computers. Achieving such low logical error rates requires quantum error correction1,2 and physical error rates below a critical threshold value3,4,5,6,7,8. We experimentally demonstrate on a trapped-ion quantum charge-coupled device (QCCD)9,10 improvements in logical error rates ranging from 11× to 800× compared with...

Nature 20h ago