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Biochemistry and Molecular Genetics

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Q&A: Why do telomeres shorten when a cell divides, and how does it affect human aging?

Q&A: Why do telomeres shorten when a cell divides, and how does it affect human aging? Stephanie Baum Scientific Editor Andrew Zinin Lead Editor In each cell of your body, DNA is stored in structures called chromosomes.

Phys.org 5d ago

Novel synthetic biomolecule degrades disease-related proteins

Novel synthetic biomolecule degrades disease-related proteins Lisa Lock Scientific Editor Robert Egan Associate Editor Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study published in Nature Communications. Shana Kelley, Ph.D., the Neena B. Schwartz Professor of Chemistry, Biomedical...

Phys.org 5d ago

Popular joint supplement glucosamine linked to faster Alzheimer’s progression

Popular joint supplement glucosamine linked to faster Alzheimer’s progression - Date: - June 10, 2026 - Source: - UF Health - Summary: - A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimer’s disease. Researchers found a 25% higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why. - Share: A widely used supplement marketed for...

Science Daily 11h ago

Lignin to adipic acid in a high-yield chemical and biological redox process

Abstract Viable manufacturing pathways to produce bio-based chemicals from renewable feedstocks, such as lignin derived from plant biomass, are needed to decarbonize the chemicals manufacturing sector. Converting the recalcitrant lignin polymer to valuable bioproducts remains a longstanding challenge in biorefining, with the highest reported single-product yield from lignin currently around 20 wt% (refs. Most existing lignin depolymerization strategies target aryl–ether bond cleavage, which...

Nature 17h ago

Researchers discover how to turn one germ's drug resistance into an Achilles' heel

Researchers discover how to turn one germ's drug resistance into an Achilles' heel Lisa Lock Scientific Editor Andrew Zinin Lead Editor Decades of reliance on the antibiotic rifampicin have fueled the rise of drug-resistant Mycobacterium tuberculosis (Mtb). But as the bacterium mutates to protect itself from the drug, it also creates new weak points that other therapies could exploit. Now, a new study published in Nature Microbiology shows that the most common rifampicin-resistance mutation...

Phys.org 8d ago

Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6

Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.

Nature 17h ago

Making climate-neutral plastics and cosmetics using bacteria

Making climate-neutral plastics and cosmetics using bacteria Sadie Harley Scientific Editor Andrew Zinin Lead Editor Plastics, medicines, cosmetics—there are very few everyday products that do not rely on using fossil resources. A European research team led by Charité—Universitätsmedizin Berlin is now aiming to revolutionize this cornerstone of the chemical industry: as part of the CarboNcare project, scientists are developing bacteria that can produce important chemical base materials from...

Phys.org 8d ago