Biomolecule
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Ubiquitin tags detected on non-protein biomolecules using new method
Nature, Published online: 03 June 2026; doi:10.1038/d41586-026-01741-zAn innovative method of mass spectrometry has detected the small protein ubiquitin on biomolecules other than proteins. In mouse liver, the energy-storing molecule glycogen has a large increase in ubiquitination — involving 1% of the liver’s total ubiquitin — during fasting, when glycogen is broken down.
Novel synthetic biomolecule degrades disease-related proteins
Novel synthetic biomolecule degrades disease-related proteins Lisa Lock Scientific Editor Robert Egan Associate Editor Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study published in Nature Communications. Shana Kelley, Ph.D., the Neena B. Schwartz Professor of Chemistry, Biomedical...
Genetically engineering cyanobacteria for the production of sulfated polysaccharide
Biomolecules are naturally occurring molecules that form the basis of living systems. They are widely used in the production of a diverse range of materials. One such widely used biomolecule is sulfated polysaccharide (SPS), which includes sugar molecules attached to sulfate groups.
Demystifying Multimodal Biomolecular Co-design With Intrinsic Geodesic Coupling
Announce Type: cross Abstract: Biomolecules such as proteins and small-molecule ligands play a central role in biological systems, arising from the tight interplay between sequence and three-dimensional structure. Recent generative models for biomolecular co-design aim to capture this interplay by jointly modeling coupled modalities.
Quantum entanglement provides a new framework for understanding chemical bonding
Chemical bonding is one of the central organizing principles of the microscopic world. It determines how atoms combine and thereby governs a wide range of physical and chemical properties of quantum systems across many length scales, ranging from small molecules and biomolecules to macroscopically large solid materials.
Recipient cell identity governs intracellular transport and membrane interactions of extracellular vesicles across species
Extracellular vesicles (EVs) function as a natural communication system, enabling transfer of biomolecules between cells. Although EVs are produced by nearly all cell types and have shown promise as therapeutic agents, our understanding of how EVs from different cellular origins recognize recipient cells, are taken up, and processed intracellularly remains limited. In particular, it remains unclear whether intracellular EV behavior is primarily governed by EV-intrinsic properties or by the...
Chemically Engineered Carbon Nanotubes Map Class-Selective Metabolite Enrichment from Human Plasma
The spontaneous adsorption of biomolecules onto nanoparticle surfaces has been extensively characterized at the protein level, but the metabolite corona remains poorly defined while being physicochemically and biologically distinctive. Herein, we report the first class-level mapping of metabolite corona composition across 25 chemically modified carbon nanotubes in human plasma using untargeted liquid chromatography-mass spectrometry. Complementary analytical conditions detected approximately...
Pocket-sized device rivals bulky lab machinery in disease and environmental testing
Pocket-sized device rivals bulky lab machinery in disease and environmental testing Lisa Lock Scientific Editor Robert Egan Associate Editor In a major advancement for decentralized health care and environmental monitoring, researchers at Kumamoto University have successfully developed a palm-sized, battery-powered spectrophotometer that matches the performance of massive commercial laboratory equipment. Published in Sensing and Bio-Sensing Research, the study reveals a 99% reduction in...
The Dirt That Refused to Die
The Dirt That Refused To Die Introduction For 15 years, Sébastien Fontaine has been trying to kill dirt. The biochemist, who runs a lab at the French National Institute for Agriculture, Food, and Environment, wanted to know how much carbon is released by soil — just dirt alone, completely devoid of life. His team sealed dirt into jars and blasted them with sterilizing gamma radiation.
DNA repair enzyme uses one-dimensional sliding to detect key sites, researchers reveal
DNA repair enzyme uses one-dimensional sliding to detect key sites, researchers reveal Sadie Harley Scientific Editor Robert Egan Associate Editor DNA is the blueprint of the human body. However, tens of thousands of DNA lesions occur in our bodies every day. In particular, if "apurinic/apyrimidinic sites" (AP sites, damaged sites where one letter of DNA information has been erased) are not properly repaired, they can lead to cancer and aging.