Bone Marrow
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Related Articles from SNS
TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma
Tyrosine kinase inhibitors (TKIs) are the first-line therapy for chronic myeloid leukemia (CML), yet fail to eliminate quiescent CML cells residing in the bone marrow (BM). While transcriptome adaptation and metabolic rewiring have been recognized as mechanisms enabling CML survival, the contribution of RNA processing, known to expand the repertoire of isoforms and directly mediate therapy resistance in leukemia, is poorly characterized. We previously found that a subset of alternative...
Piezo1 transduces mechanical signals to inhibit osteoclast fusion and coordinate bone homeostasis
Osteoclasts originate from bone marrow-derived macrophages, and their maturation relies on fusion of pre-osteoclasts into mature osteoclasts that maintain bone homeostasis. Previous studies established that mechanical signals regulate osteoblast activity in bone homeostasis, although whether such signals regulate bone homeostasis by acting on osteoclasts remains unclear. Herein, membrane tension decreased during pre-osteoclast fusion, accompanied by reduced Piezo1.
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Epileptic teen donated his organs to save three other people thanks to inspiring headteacher
Epileptic teen donated his organs to save three other people thanks to inspiring headteacher EXCLUSIVE: Patrick Leonard, 18, died of a catastrophic epileptic fit before his organs went to save the life of three other patients A teenager donated his organs to save three other people following a catastrophic epileptic fit. Patrick Leonard, 18, was inspired by his headteacher - who told a school assembly how he had had become a bone marrow and stem cell donor with the charity Anthony Nolan - to...
UK’s stem cell transplant system may be putting lives at risk, report by MPs finds
System not fit for purpose due to poor infrastructure and planning, with minority groups particularly at risk, MPs sayThe UK’s stem cell transplant system is potentially putting the lives of blood cancer patients at risk as a result of inadequate infrastructure and a lack of long-term planning, a parliamentary report has found. A hematopoietic stem cell transplant, often referred to as a bone marrow transplant, is a medical procedure in which stem cells from a healthy donor are transplanted...
p38 dependent IL-33 responses define a conserved inflammatory programme in mast cells
Interleukin-33 (IL-33) is a key cytokine in mast cell mediated immunity, promoting inflammatory cytokine production without inducing degranulation. Here, we compared IL-33 induced proteomic responses across three mast cell culture systems, Foetal Liver derived Mast Cells (FLMCs), Bone Marrow derived Mast Cells (BMMCs), and Peritoneal Mast Cells (PMCs), using quantitative data-independent acquisition mass spectrometry. Although baseline proteomes were largely conserved across all mast cell...
The Happy Pod: Christmas with the man I saved
A US woman whose bone marrow saved a father of three in Australia has spent Christmas with him and his family. Gennaro Rapinese, whose leukaemia was cured by the donation, greeted Cassidy Feeney at the airport in Perth with the words 'you saved my life'. Cassidy, who'd never met Gennaro before, says she decided to donate because she'd want someone to do the same for her loved ones - and believes everyone should care more about others and less about themselves.
UK’s stem cell transplant system may be putting lives at risk, report by MPs finds
System not fit for purpose due to poor infrastructure and planning, with minority groups particularly at risk, MPs sayThe UK’s stem cell transplant system is potentially putting the lives of blood cancer patients at risk as a result of inadequate infrastructure and a lack of long-term planning, a parliamentary report has found. A hematopoietic stem cell transplant, often referred to as a bone marrow transplant, is a medical procedure in which stem cells from a healthy donor are transplanted...
Immunomodulatory Effects of Insulin-Derived Fibrils from Infusion Pumps: Role of Phenolic Preservatives in Macrophage Activation
Background: Protein fibrillation represents a critical challenge in therapeutic insulin delivery, yet the structural determinants and immunological consequences of insulin-derived fibrils (IDFs) formed in the presence of phenolic preservatives remain poorly characterized. This study investigated the structural characteristics of IDFs formed with (IDF (+)) and without (IDF (-)) phenolic preservatives and elucidated their differential immunomodulatory mechanisms in bone marrow-derived...
Cancer’s favorite escape trick may actually make it easier to kill
Cancer’s favorite escape trick may actually make it easier to kill - Date: - June 4, 2026 - Source: - Baylor College of Medicine - Summary: - Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a key immune-recognition molecule called MHC I—a common trick used to hide from “killer” T cells—they can actually become more vulnerable to attack by a...