Bone Marrow Transplant
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UK’s stem cell transplant system may be putting lives at risk, report by MPs finds
System not fit for purpose due to poor infrastructure and planning, with minority groups particularly at risk, MPs sayThe UK’s stem cell transplant system is potentially putting the lives of blood cancer patients at risk as a result of inadequate infrastructure and a lack of long-term planning, a parliamentary report has found. A hematopoietic stem cell transplant, often referred to as a bone marrow transplant, is a medical procedure in which stem cells from a healthy donor are transplanted...
UK’s stem cell transplant system may be putting lives at risk, report by MPs finds
System not fit for purpose due to poor infrastructure and planning, with minority groups particularly at risk, MPs sayThe UK’s stem cell transplant system is potentially putting the lives of blood cancer patients at risk as a result of inadequate infrastructure and a lack of long-term planning, a parliamentary report has found. A hematopoietic stem cell transplant, often referred to as a bone marrow transplant, is a medical procedure in which stem cells from a healthy donor are transplanted...
Cancer’s favorite escape trick may actually make it easier to kill
Cancer’s favorite escape trick may actually make it easier to kill - Date: - June 4, 2026 - Source: - Baylor College of Medicine - Summary: - Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a key immune-recognition molecule called MHC I—a common trick used to hide from “killer” T cells—they can actually become more vulnerable to attack by a...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Epileptic teen donated his organs to save three other people thanks to inspiring headteacher
Epileptic teen donated his organs to save three other people thanks to inspiring headteacher EXCLUSIVE: Patrick Leonard, 18, died of a catastrophic epileptic fit before his organs went to save the life of three other patients A teenager donated his organs to save three other people following a catastrophic epileptic fit. Patrick Leonard, 18, was inspired by his headteacher - who told a school assembly how he had had become a bone marrow and stem cell donor with the charity Anthony Nolan - to...
Gut Microbiota Dysbiosis Drives Myocardial Hypertrophy Through GBP2b/GBP1-Mediated Immune Reprogramming and Exosomal Signaling in Chronic Colitis
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk of cardiovascular disease, yet the mechanisms linking chronic intestinal inflammation to cardiac dysfunction remain poorly understood. IBD is characterized by profound gut microbiota dysbiosis, which we hypothesize drives systemic immune dysregulation and contributes to cardiac dysfunction. A chronic colitis mouse model was used to assess gut microbiota dysbiosis, systemic immune cell metabolism, and cardiac...
Probabilistic learning to perform pre-onset individualised prediction of disease severity: application to Veno Occlusive Disease
arXiv:2606.06516v1 Announce Type: cross Abstract: We advance a new probabilistic supervised learning approach that permits reliable, automated, and early individualised prediction of the severity with which a disease will develop in a prospective patient. The prediction capacity is illustrated via the pre-transplant prediction of the score of severity of Veno Occlusive Disease (or VOD) in the digital twin (DT) of the considered prospective patient, where this score parametrises the severity...
'I've got six months to live - leaving my twin sister at 24 is unthinkable'
'I've got six months to live - leaving my twin sister at 24 is unthinkable' Caitlin Leggett is trying to raise £500,000 A 24-year-old twin given just six months to live after her leukaemia came back is attempting to raise £500,000 for potentially life-saving treatment abroad, saying the prospect of leaving her identical sister behind is "unthinkable". Caitlin Leggett, from Cardiff, was diagnosed with acute myeloid leukaemia – an aggressive cancer of the white blood cells – in April 2025,...
Cancer patient's stem cell transplant struggle highlights need for more donors
Young cancer patient's stem cell transplant struggle highlights shortage of local donors Wed 3 Jun 2026 at 7:30am In December last year, Sarah Taylor started feeling fatigued. She suffered nosebleeds and experienced prolonged periods. As the months went on, her symptoms worsened, forcing her to quit her job and leaving her unable to get out of bed.