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Combinatorial screening of nanoparticles for nose-to-brain RNA delivery to modulate neuroinflammation after traumatic brain injury
Traumatic brain injury (TBI)-induced neuroinflammation can evolve over weeks or months,contributing to ongoing secondary damage and worsening neurological recovery. RNA-based therapeutics hold great potential to regulate inflammatory signaling, but delivery to the brain remains challenging because of the blood brain barrier. Intranasal administration offers a direct non-invasive route for brain access but is often limited by low delivery efficiency.
Age and Gender-Dependent Group-Average Brain Biomechanics Models for Traumatic Brain Injury
Experimental studies involving mechanical loading of the human head and brain in vivo are necessarily limited, making computational modeling essential for advancing our understanding of brain biomechanics. Demographic factors such as age and gender are known to influence brain anatomical structures, material properties, and potentially vulnerability to injurious loading. To address this, we construct six group-average brain models stratified by age and gender from a total of 135 subjects,...
High-order brain interactions distinguish wakefulness, anaesthesia, and recovery induced by deep brain stimulation
Understanding how consciousness depends on large-scale brain interactions is key for both the neuroscience of consciousness and clinical translation. However, it requires moving beyond classical pairwise descriptions of functional connectivity, which cannot capture the collective dependencies emerging across multiple brain regions. Here, we use multivariate information theory measures to characterize how higher-order interactions reorganize across states of consciousness.
Quilting the Brain: Whole-Brain iEEG Reconstruction via Incomplete Observation Linear Mixed Models
Mapping human brain function at high spatiotemporal resolution is constrained by the physical limitations of non-invasive imaging and the sparse sampling of invasive electrophysiology. While intracranial electroencephalography (iEEG) captures local field potentials with millimeter precision, clinical implantation strategies result in a ``coverage paradox'': observations are restricted to disjoint, patient-specific patches, leaving most of the cortex unobserved. This study introduces the...
Your brain starts making social decisions before you do
Your brain starts making social decisions before you do - Date: - June 2, 2026 - Source: - The Hebrew University of Jerusalem - Summary: - Researchers found that social behavior begins in the brain before it becomes visible as movement. In zebrafish, a coordinated pattern of activity spread across the brain several seconds before the animals approached another fish. A higher brain region called the pallium played a key role, and fish with stronger neural signals were generally more social.
Intermittent fasting triggers surprising changes in the brain
Intermittent fasting triggers surprising changes in the brain An intermittent fasting-style diet helped obese adults lose weight while triggering coordinated changes in both their gut bacteria and brain activity. - Date: - May 31, 2026 - Source: - Frontiers - Summary: - Losing weight may involve rewiring the gut and the brain at the same time. In a study of obese adults, an intermittent fasting-style diet led to significant weight loss, healthier metabolic markers, and notable shifts in gut...
Brain scans reveal two distinct types of autism
Brain scans reveal two distinct types of autism Scientists have revealed two hidden brain-based forms of autism, a breakthrough that could help tailor future treatments to each person's biology. - Date: - June 3, 2026 - Source: - Istituto Italiano di Tecnologia - IIT - Summary: - Scientists have uncovered evidence that autism may include at least two biologically distinct subtypes, each marked by a different pattern of brain communication.
Real-time fish interaction enlarges young guppy brains, while screen time falls short
Real-time fish interaction enlarges young guppy brains, while screen time falls short Sadie Harley Scientific Editor Robert Egan Associate Editor Young guppies who were able to see and interact with live fish developed larger brains than guppies who only saw other fish on a screen. This is shown in a new study from Stockholm University, published in Biology Letters. The findings suggest that live social interaction in real time may be important for brain development.
Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists found the hidden switch fueling alzheimer’s brain inflammation Scientists may have found a hidden Alzheimer’s “inflammation switch”—and turning it off protected brain connections in early studies. - Date: - May 31, 2026 - Source: - Scripps Research Institute - Summary: - Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically...
Scientists discover the brain chemical that helps you break bad habits
Scientists discover the brain chemical that helps you break bad habits Scientists have identified a brain chemical that appears to turn disappointment into a powerful trigger for change. - Date: - June 8, 2026 - Source: - Okinawa Institute of Science and Technology (OIST) Graduate University - Summary: - Scientists have uncovered a key brain signal that helps us break old habits and adapt when circumstances suddenly change.