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Neurodevelopmental Inequality arising from Early Childhood Stunting: Evidences from Brain Connectivity
Early childhood stunting (ECS) affects millions of children globally and conjectured to result in suboptimal brain and cognitive development later in life. Charting out the trajectory of brain network development and most importantly how the compensation of function can be achieved gives windows of intervention to clinicians, educators and policy makers. In this study, advanced network neuroscience tools, graph theoretical methods applied on diffusion weighted MR-imaging (DWI) revealed the...
Learning Multi-Scale Hypergraph for High-Order Brain Connectivity Analysis
Announce Type: new Abstract: Understanding complex interactions between brain regions is critical for early neurodegenerative disease classification such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). While graph-based models are widely used to analyze brain networks, most existing approaches primarily focus on pairwise interactions between directly connected nodes, limiting their ability to capture higher-order dependencies across multiple regions. Although hypergraph-based...
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists found the hidden switch fueling alzheimer’s brain inflammation Scientists may have found a hidden Alzheimer’s “inflammation switch”—and turning it off protected brain connections in early studies. - Date: - May 31, 2026 - Source: - Scripps Research Institute - Summary: - Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically...
Cortical folding patterns are encoded in the geometry of the unfolded neocortex.
Cortical folding patterns are conserved across individuals of gyrencephalic species and are closely related to cytoarchitectural organisation, connectivity, and function. Early morphogen gradients have been proposed as the molecular source of positional information encoding these patterns - a gyral molecular protomap - but the contribution of neocortical geometry to this encoding has not been examined. Here we show that the geometry of the unfolded ferret brain guides the adult folding...
Why you need to future proof your brain in middle age and how to start
To chart how our brains change over the course of our lives, neuroscientists have focused largely on beginnings and endings: the rapid development and pruning of neural connections in childhood and adolescence, and the degeneration associated with old age. “We kind of skipped over middle age,” says Sebastian Dohm-Hansen, a bioinformatician at University College Cork in Ireland. There are good reasons for that, not least that changes in brain structure and function are easier to spot with...
Starting kindergarten soon? Summer is a perfect time to support a child's early literacy learning
Starting kindergarten soon? Summer is a perfect time to support a child's early literacy learning Sadie Harley Scientific Editor Andrew Zinin Lead Editor The first day of kindergarten is a momentous occasion for children and families. It's an exciting milestone that comes with new friends, teachers, and learning opportunities.
Scientists reveal surprising brain benefit of laughter: 'It's a mental workout'
The old saying that laughter is the best medicine may be true, according to new research that suggests it is also a vital catalyst for children's development. Laughter and play are fundamental to healthy brain growth, emotional well-being and social bonding, according to Jacqueline Harding, Ph.D., an early childhood expert at Middlesex University in London. In her book, "The Brain That Loves to Laugh," Harding argues that joy is a complex biological phenomenon that helps children navigate...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Peter Phillips' new wife Harriet Sperling's private life from NHS nurse to royal
Peter Phillips' new wife Harriet Sperling's private life from NHS nurse to royal Princess Anne's son Peter Phillips is marrying NHS nurse Harriet Sperling, two years after they first met, with senior royals on hand to welcome the newest member of the Royal Family It is one of the most high-profile weddings of the year and will see the bride complete her journey today from NHS nurse to the Royal Family's newest member. Peter Phillips, the son of Princess Anne, is set to marry fiancée Harriet...