Bridging Adaptive Evolution and Rational Design for Synthetic Biology Genome
No mentions found
This entity hasn't been tracked yet, or Iris is still building its knowledge base.
Related Articles from SNS
Dual-Chassis Strategy for Bridging Adaptive Evolution and Rational Design for Synthetic Biology
Genome streamlining and pathway refactoring are powerful strategies for constructing controllable microbial chassis for both fundamental studies and applications. While rational design benefits from reduced genetic complexity, adaptive laboratory evolution (ALE) thrives on metabolic redundancy, creating a mismatch between optimal hosts for design and evolution. Here, we introduce a dual chassis framework (DUET) in which rational pathway construction and adaptive evolution are first carried...