C.C. Wei
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SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Measurement of reactor neutrino oscillation with the first JUNO data
Abstract Neutrino oscillations (see refs. 1,2 and references therein), a quantum effect manifesting at macroscopic scales, are governed by lepton flavour mixing angles and neutrino mass-squared differences3 that are fundamental parameters of particle physics, representing phenomena beyond the Standard Model. Precision measurements of these parameters are essential for testing the completeness of the three-flavour framework, determining the mass ordering of neutrinos and probing possible new...
New solar desalination breakthrough makes fresh water without toxic brine
New solar desalination breakthrough makes fresh water without toxic brine This sunlight-powered desalination breakthrough turns seawater into fresh water while harvesting valuable minerals. - Date: - May 31, 2026 - Source: - University of Rochester - Summary: - Scientists have developed a solar desalination system that turns seawater into drinking water without creating environmentally damaging brine. Special laser-textured metal panels use sunlight to evaporate water while automatically...
New solar desalination breakthrough makes fresh water without toxic brine
New solar desalination breakthrough makes fresh water without toxic brine This sunlight-powered desalination breakthrough turns seawater into fresh water while harvesting valuable minerals. - Date: - May 31, 2026 - Source: - University of Rochester - Summary: - Scientists have developed a solar desalination system that turns seawater into drinking water without creating environmentally damaging brine. Special laser-textured metal panels use sunlight to evaporate water while automatically...
Doctors thought this kidney drug helped some patients. It may help millions more.
Doctors thought this kidney drug helped some patients. It may help millions more. - Date: - June 8, 2026
A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone
Abstract Whale falls are biodiversity oases at seabeds1,2,3,4,5,6, yet their record from the oceans has remained sparse and fragmentary6,7. Here we report the discovery of a vast whale necropolis in the Diamantina Zone (4,616- to 7,001-m depth), extending about 1,200 km along the sea floor of the southeastern Indian Ocean. This area has a deep and extensive accumulation comprising five modern natural whale-fall communities and 476 fossil cetaceans recorded.
World's largest opioid review finds they often don't work
World's largest opioid review finds they often don't work - Date: - June 9, 2026 - Source: - University of Sydney - Summary: - The largest review ever conducted on opioids for acute pain found that these widely prescribed drugs often deliver only small, short-lived benefits. For many common conditions, including some surgeries and kidney stone pain, opioids performed no better than a placebo.
Scientists mapped every neural connection in a fruit fly and found a surprise
Scientists mapped every neural connection in a fruit fly and found a surprise Scientists have completed the first full brain-to-body wiring map of a fruit fly, revealing that behavior may be driven more by local neural teamwork than by a central brain command center. - Date: - June 10, 2026 - Source: - Harvard Medical School - Summary: - A groundbreaking new connectome maps every neural connection in an adult fruit fly’s central nervous system, creating an unprecedented view of how the brain...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).