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Related Articles from SNS
Functional class 2 CCA-adding enzymes in Asgard archaea and their implications for eukaryogenesis
CCA-adding enzymes are essential for transfer RNA (tRNA) maturation and translation among all domains of life. A long standing dogma holds that archaea encode exclusively class one CCA-adding enzymes (CCA1), whereas bacteria and eukaryotes encode class two enzymes (CCA2), creating a perceived strict evolutionary separation between archaeal and eukaryotic CCA adding enzymes. Here, we show that this view is incorrect.
Multivariate integration of histological images and gene expression data: a comparative review
Integrating histological images with gene expression data offers a promising approach for linking tissue morphologies to molecular signatures and improving disease subtyping. However, such integration remains challenging due to the high dimensionality of these datasets, cross-modal heterogeneity, and limited interpretability. Multivariate methods such as Sparse Canonical Correlation Analysis (Sparse CCA), Joint Nonnegative Matrix Factorisation (Joint NMF), and Angle-based Joint and...