COCONUT
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Mapping Chemical Diversity: Descriptor-Guided Clustering of Natural Products in the COCONUT Database
Natural products represent a major source of bioactive compounds for drug discovery, yet their exploration remains challenging due to extensive structural complexity and scaffold diversity. Using the COCONUT database, we developed a cluster-oriented framework to systematically map and characterize the natural product chemical space through feature engineering, molecular clustering, and representative-based analysis. Descriptor selection identified a greedy maximum coverage strategy with a...
Entrepreneur Asyraf Rasheed on why he brought popular Indonesian nasi padang chain Sederhana to Singapore
Entrepreneur Asyraf Rasheed on why he brought popular Indonesian nasi padang chain Sederhana to Singapore “We’re not trying to take over anyone’s legacy,” biotechnologist turned F&B entrepreneur Asyraf Rasheed, 33, tells 8days.sg. Why did he bring the Indonesian chain Sederhana to where the heritage Singaporean nasi padang joint Warong Nasi Pariaman once stood? When Warong Nasi Pariaman shuttered in January after 78 years, many wondered what could possibly replace the beloved Kampong Glam...
Violence brokers, teen hitmen and the new era of 'disorganised crime'
Sydney's fired-up gangland a new era of 'disorganised crime' as police target powerful violence brokers Tue 9 Jun 2026 at 5:57am A drive-by shooting targeting a funeral is just another sign that Sydney's gangland scene has entered a new era of "disorganised crime", according to a senior police officer. Sydney's organised crime figures used to rely on trusted individuals to carry out sophisticated and targeted attacks on rivals in the dead of night. Some hits were motivated by unpaid debts...
Curries to make winter meals tasty and affordable
Easy and affordable curries to bring some winter warmth Mon 1 Jun 2026 at 2:54pm Winter is officially here, and if you're looking to bring some warmth to your meals, these curries are big on flavour and low on cost. You can easily vary the heat levels of each dish to suit your taste. And as a bonus, some of the recipes also offer immune-boosting properties to help ward off cold-weather lurgies.
Where to buy rice dumplings in Singapore for Dragon Boat Festival 2026
Where to buy rice dumplings in Singapore for Dragon Boat Festival 2026 From traditional Nyonya and Hokkien bak zhang to jumbo abalone creations, chilli crab dumplings and durian kee zhang, here are some of the season’s most tempting rice dumplings. Come the fifth day of the fifth lunar month, which falls on Jun 19 this year, many of us will tuck into a fragrant rice dumpling to commemorate the dragon boat festival. Perhaps the hardest decision, if you’re tasked with buying said rice...
Mourners farewell gangster a day after gunman targets wrong funeral venue
Dozens of mourners have turned out to farewell Sydney crime boss Lorenzo Lemalu at a funeral held at Lakemba Mosque, in Sydney's western suburbs. The procession was held just 24 hours after police responded to reports of a gunman firing shots into another venue that was advertised as the location of Lemalu’s funeral. Lemalu's death has heightened gangland tensions in Sydney, with police sources saying they are braced for reprisal attacks.
Desi jugaads during heatwaves: India’s battle against 45°C temperatures
India is learning to live with a hotter future. From Delhi to Mumbai, temperatures are regularly crossing 45 degrees Celsius, heatwaves are lasting longer and cities are becoming giant heat traps due to rapid urbanisation and the growing urban heat island effect. But if there is one thing Indians are famous for, it is finding a jugaad for every problem.
Warm compress, cold packs, Epsom salt bath: How to do 6 home therapies properly according to physios
Warm compress, cold packs, Epsom salt bath: How to do 6 home therapies properly according to physios They seem easy to prep but how hot should the water be and how long do you use these home therapies for pain, swelling or recovery? Physiotherapists explain what works and what to avoid doing. If you’ve just had haemorrhoid surgery or are living with a boba-sized stye on your eyelid, you might have been advised by the doctor to prep a home therapy such as a sitz bath or warm compress.
A 7.8 magnitude quake in the Philippines kills at least 32, collapses buildings and sparks tsunami
An offshore magnitude 7.8 earthquake hit the southern Philippines on Monday, killing at least 32 people, injuring more than 200 others mostly in ruined buildings and sending a 1-meter (3-foot) tsunami into nearby coasts. Several mostly low-rise buildings collapsed or sustained heavy damages in the hard-hit city of General Santos. Tsunami damage was reported in at least one southern coastal village.
Two charged over shooting at wrong funeral venue for Sydney crime boss
Two charged over shooting at wrong funeral venue for Sydney crime boss Lorenzo Lemalu Tue 9 Jun 2026 at 1:46pm Two people have been charged over a shooting at a venue in Sydney's south-west that was advertised to be hosting a funeral for a crime boss who was killed in Vietnam. Police on Saturday afternoon responded to reports shots had been fired at a Punchbowl venue, with video shared on social media appearing to show gunmen shooting from inside a car at the property.