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Related Articles from SNS
Harry's and Coterie owner Mammoth Brands has ambitions to be the next CPG giant
Mammoth Brands wants to take on traditional consumer packaged goods companies, armed with a portfolio of disruptors in the personal and baby care categories that have won over consumers and retailers alike. For the last decade, upstarts like those owned by Mammoth have challenged the relevance and longstanding dominance of legacy giants like Procter & Gamble, Unilever and Kimberly-Clark. The trend has also played out across packaged food and beverage companies, like Poppi and Olipop taking...
Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and alleles
Epigenetic state modulates gene regulation in a manner not always predictable from DNA sequence alone, yet current genomic deep learning models do not leverage epigenetic state as input. We present MethylSeqNet, a model that conditions pretrained sequence embeddings on CpG methylation, a stable epigenetic mark increasingly available from long-read sequencing data. Using a novel conditioning mechanism enabling scalability and interpretability, MethylSeqNet improves predictions in cases where...
Improving the Accuracy of Forensic Age Estimation Through Bias Reduction
Chronological age estimation can provide supporting information in forensic casework when traditional identification methods are limited. DNA methylation, a stable epigenetic mark, has emerged as a promising tool for predicting chronological age from trace samples. However, many existing age estimation models rely on linear regression approaches, which often yield biased prediction errors across the age distribution (i.e. model residuals show a significant age dependence).
A Fast Screening Approach for High-dimensional Outcomes and High-dimensional Predictors
Announce Type: cross Abstract: Modeling interactions among multimodal, high-dimensional data is intrinsically challenging due to ultra-high dimensionality and complex dependence structure with high level noise. Screening methods are effective for reducing dimensionality, but most existing approaches shrink only the predictor space while retaining all outcomes. In cross-modal analyses, different outcomes often select different predictor subsets, so the union remains large and the response...
Nuclear confinement from matrix stiffness drives epigenomic reprogramming of gingival fibroblasts
Periodontal disease is characterized by progressive degradation of the gingival extracellular matrix and loss of the physical confinement it imposes on resident stromal cells. In human periodontal tissue, ECM collagen integrity is inversely correlated with facultative nuclear histone acetylation in stromal cells. We hypothesized that matrix stiffness directly coordinates an epigenomic shift in stromal cells.
Multiple approaches for CRISPR-based targeting of DNA methylation to promoters of bacterial and viral susceptibility genes in cassava
Targeted epigenetic modifications of specific gene regulatory regions have the potential to confer beneficial traits for crop improvement. Two recently developed CRISPR/Cas9-based epigenome editing tools were tested in transgenic cassava to target cytosine methylation to the promoter region of MeSWEET10a, a necessary gene for infection by the Cassava bacterial blight pathogen, Xanthomonas phaseoli pv. manihotis. The two systems leverage unique methyltransferases, and each induced distinct...
An inflammatory gene set driven epigenetic clock tracks down disease progression and rejuvenation
Chronic, low-level inflammation, characterized by elevated pro-inflammatory programs, including epigenetic changes, in the absence of infection, is a major driver of aging and age-related diseases. On the other side of the spectrum, aging interventions work, at least in part, by decreasing inflammation. However, the molecular connection between epigenetic aging and inflammatory profiles in chronic diseases and rejuvenation has not been established yet.
Fasting Status and Epigenetic Clock Stability: Implications for Aging Research
Background: Epigenetic clocks are DNA methylation-based biomarkers increasingly used in aging research and clinical trials. A recent assessment of 18 clocks across multiple short-term perturbations concluded that most demonstrate only moderate biological reliability, raising concerns about their translational utility. However, understanding biological variability requires understanding the construction of each clock: different clocks capture distinct biological properties that respond...
Ancient cave lion genomes reveal a distinct lineage
Ancient cave lion genomes reveal a distinct lineage Sadie Harley Scientific Editor Robert Egan Associate Editor A new study on multiple genomes from the extinct cave lion has discovered that it represented a highly distinct evolutionary lineage, which separated from modern lions more than a million years ago. The results also show that the cave lion had a history of interbreeding with modern lions that was tightly linked to past climatic changes. These findings are published in the journal...