CellProfiler
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Related Articles from SNS
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
Morphology-robust quantification of subcellular organization in complex cells
Quantitative analysis of subcellular protein organization is often confounded by variation in cell morphology, limiting the identification and interpretation of localization patterns in fluorescence microscopy data from morphologically complex cells, such as neurons and glia. We introduce CellAligner, an unsupervised framework that uses fused unbalanced Gromov-Wasserstein couplings to map protein distributions from morphologically distinct cells into shared anchor-cell geometries, enabling...