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Circular Active Nano

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Targeting lncRNA JINR1 with programmable Circular Active Nano DNAzyme (CANDe) suppresses Japanese Encephalitis Virus infection

Oligonucleotide therapeutics such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) enable sequence-specific gene silencing but rely on endogenous cellular machinery and often require extensive chemical modification for stability and efficacy. DNAzymes offer a mechanistically distinct alternative through intrinsic catalytic RNA cleavage; however, their therapeutic translation has been limited by nuclease susceptibility, structural constraints, and synthetic challenges....

bioRxiv 9d ago

Reliability-Guided Depth Fusion for Glare-Resilient Navigation Costmaps

Announce Type: new Abstract: Specular glare on reflective floors, glass boundaries, and glossy indoor surfaces frequently corrupts active-stereo RGB-D depth measurements, producing holes and spikes that accumulate as persistent phantom obstacles in occupancy-grid costmaps. This paper presents a glare-resilient costmap construction method based on explicit depth-reliability modeling. A lightweight Depth Reliability Map network (DRM-Net) predicts per-pixel measurement trustworthiness under...

arXiv CS 7d ago